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Antimuscarinic drugs: review of the cognitive impact when used to treat overactive bladder in elderly patients.

Author: GuralnickMichael L, O'ConnorR Corey, PagoriaDustin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Antimuscarinics are used to treat overactive bladder (OAB), but some can cause cognitive side effects. Oxybutynin can adversely affect cognition in elderly patients, while darifenacin, trospium, solifenacin, and tolterodine appear to be safe for this population.
Paper Details　
Original Abstract of the Article :
The blockade of muscarinic receptors in the management of overactive bladder (OAB) symptoms provides beneficial as well as adverse effects. The cognitive changes observed are caused by the drugs' ability to cross the blood-brain barrier and bind to muscarinic receptors within the central nervous sys...See full text at original site
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引用元：
https://doi.org/10.1007/s11934-011-0198-9

データ提供：米国国立医学図書館（NLM）

Antimuscarinics: Navigating the Cognitive Landscape

This research delves into the complex relationship between [antimuscarinic drugs] and [cognitive function], particularly in [elderly patients with overactive bladder]. The authors highlight the potential [cognitive side effects] of [antimuscarinics] due to their ability to [cross the blood-brain barrier and bind to muscarinic receptors] in the [central nervous system]. While most studies have not shown [significant cognitive impairment], the authors emphasize the need for [caution in elderly patients with preexisting dementia].

Cognitive Function: A Delicate Balance

This research demonstrates that [antimuscarinic drugs] can have [a variable impact on cognitive function], with some drugs like [oxybutynin] showing [negative effects], while others like [darifenacin, trospium, solifenacin, and tolterodine] appear to have [minimal cognitive risk]. This highlights the importance of [individualized treatment] and [close monitoring] for [elderly patients taking antimuscarinics].

Overactive Bladder: A Complex Condition

The study reminds us that [overactive bladder] is a common condition in [the elderly] and that [treatment] must consider not only [bladder control] but also [cognitive function]. It underscores the importance of [understanding the potential side effects] of [medications] and [making informed decisions] about [treatment options].

Dr. Camel's Conclusion

This research is a reminder that the human body is a complex system and that even seemingly simple treatments like [antimuscarinic drugs] can have [unforeseen consequences]. We must be diligent in [evaluating the potential risks and benefits] of any medication, especially in vulnerable populations like the elderly.

Date :
  1. Date Completed 2012-02-01
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21607875

DOI: Digital Object Identifier

10.1007/s11934-011-0198-9

SNS
PICO Info
in preparation
Languages

English

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