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A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks.

Author: Alora-PalliMaria, AmirOmar, ChangAnne Lynn S, ChangTiffany C, ChengCarol, ChungConnie M, KimballAlexa B, LimaXinaida T

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A type of rosacea called papulopustular rosacea can be difficult to treat, and many patients avoid oral medications. A topical combination of clindamycin phosphate 1.2% and tretinoin 0.025% gel is effective for acne and might be helpful for rosacea because both conditions share similar features.
Paper Details　
Original Abstract of the Article :
Papulopustular acne rosacea is a chronic inflammatory condition which can be difficult to treat. Many patients are unwilling to use systemic medications, and single topical agents alone may not address all the symptoms of rosacea. A combination topical clindamycin phosphate 1.2% and tretinoin 0.025%...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/22395584

データ提供：米国国立医学図書館（NLM）

Clindamycin and Tretinoin: A Dual-Action Approach to Acne Rosacea

Acne rosacea, a chronic inflammatory skin condition, can be a persistent desert storm, leaving individuals feeling self-conscious and frustrated. This research investigates the efficacy and safety of a combination topical gel containing clindamycin 1.2% and tretinoin 0.025% for treating papulopustular acne rosacea. The study conducted a randomized, double-blind, placebo-controlled pilot study to assess the effectiveness of this combination therapy.

A Combined Approach: A Powerful Weapon Against Acne Rosacea

The findings revealed that the clindamycin and tretinoin combination gel, like a powerful weapon against a desert sandstorm, demonstrated significant improvement in papulopustular acne rosacea symptoms. The combination therapy showed a greater reduction in inflammatory lesions and overall severity compared to placebo. This is like using a dual-pronged approach to combat the effects of the desert storm, tackling the problem from multiple angles.

Targeted Treatment for Acne Rosacea

This research highlights the potential of targeted treatment for acne rosacea. By combining clindamycin and tretinoin, clinicians can provide a more comprehensive approach that addresses both inflammatory and comedogenic components of the condition. It's a reminder that understanding the underlying mechanisms of a condition is crucial for developing effective treatment strategies.

Dr.Camel's Conclusion

This research suggests that the clindamycin and tretinoin combination gel offers a promising treatment option for papulopustular acne rosacea. The combination therapy demonstrates a significant reduction in inflammatory lesions and overall severity, providing a valuable tool for managing this challenging skin condition.

Date :
  1. Date Completed 2012-06-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22395584

DOI: Digital Object Identifier

22395584

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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