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A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial.

Author: , BathonJoan M, BridgesS Louis, CofieldStacey S, CurtisJeffrey R, HowardGeorge, McVieTheresa, MorelandLarry W, O'DellJames R, PaulusHarold E, St ClairE William, ZhangJie, van der HeijdeDésirée

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compares two approaches to treating early rheumatoid arthritis (RA): 1. **Intensive treatment:** All patients receive a combination of medications from the start. 2. **Step-up approach:** Patients initially receive a single medication (methotrexate, MTX). If their disease activity remains high after 24 weeks, they are switched to combination therapy. The study also investigates whether combining MTX with etanercept (a type of biologic drug) is more effective than combining MTX with sulfasalazine and hydroxychloroquine (two commonly used medications).
Paper Details　
Original Abstract of the Article :
To assess whether it is better to intensively treat all patients with early rheumatoid arthritis (RA) using combinations of drugs or to reserve this approach for patients who do not have an appropriate response (as determined by a Disease Activity Score in 28 joints using the erythrocyte sedimentati...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/22508468

データ提供：米国国立医学図書館（NLM）

Early Aggressive Rheumatoid Arthritis: Finding the Right Treatment Path

Rheumatoid arthritis (RA), a chronic inflammatory disease, can lead to significant pain and disability. This study investigates the optimal treatment approach for early aggressive RA, comparing intensive combination therapy with methotrexate (MTX) plus etanercept to a strategy of reserving combination therapy for patients who do not respond adequately to MTX monotherapy. The researchers aimed to determine the most effective and efficient treatment strategy to manage RA in its early stages.

Intensive Combination Therapy: A Promising Approach for Early RA

The study found that intensive combination therapy with MTX plus etanercept was more effective in managing early aggressive RA than reserving combination therapy for patients who did not respond well to MTX monotherapy. The researchers conclude that initiating intensive combination therapy early in the disease course can lead to better long-term outcomes. However, they acknowledge the need for further research to explore the long-term effects of different treatment strategies and the potential for personalized approaches based on individual patient characteristics.

Navigating the Rocky Terrain of Rheumatoid Arthritis

This research provides valuable insights into the optimal treatment strategies for early aggressive RA. It underscores the importance of early intervention and highlights the potential benefits of intensive combination therapy in managing this challenging condition. It also emphasizes the need for ongoing research to personalize treatment approaches and improve patient outcomes. Working closely with your doctor to develop a treatment plan that meets your individual needs can help you navigate the rocky terrain of RA and manage your condition effectively.

Dr. Camel's Conclusion

Navigating the desert of rheumatoid arthritis can be a challenging journey, but this study offers valuable guidance. Early intervention and personalized treatment strategies can help manage this condition effectively, providing a more comfortable and manageable future for those affected by RA.

Date :
  1. Date Completed 2012-12-04
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22508468

DOI: Digital Object Identifier

NIHMS574426

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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