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A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study.

Author: ChenKai, ChenLijuan, ChenLili, GuRan, HuYue, JiaWeijuan, JinLiang, LiShunrong, LongMeijun, RaoNanyan, SongErwei, SuFengxi, WuJiannan, WuMei, XiaoQiaozhen, ZengYunjie

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This retrospective study sought to establish the role of toremifene as an endocrine therapy for premenopausal patients with estrogen and/or progesterone receptor positive breast cancer besides tamoxifen.
Paper Details　
Original Abstract of the Article :
In premenopausal women, endocrine adjuvant therapy for breast cancer primarily consists of tamoxifen alone or with ovarian suppressive strategies. Toremifene is a chlorinated derivative of tamoxifen, but with a superior risk-benefit profile. In this retrospective study, we sought to establish the ro...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503787/

データ提供：米国国立医学図書館（NLM）

A Comparative Study: Toremifene vs. Tamoxifen for Breast Cancer

This research focuses on the [treatment of estrogen and progesterone receptor-positive breast cancer] in [premenopausal women]. The researchers [compared the survival outcomes and side effects of toremifene and tamoxifen], two common endocrine therapies, [using a retrospective cohort study]. The study aimed to [establish the role of toremifene] as a [viable alternative] to tamoxifen in this population.

Toremifene Emerges as a Promising Alternative

The study [found no significant differences] in [survival outcomes] between [toremifene and tamoxifen]. However, [toremifene demonstrated a superior risk-benefit profile] with [fewer side effects]. This research [suggests that toremifene] may be [a favorable treatment option] for [premenopausal women with breast cancer]. This study is like a [desert expedition], [discovering new pathways] to [better breast cancer treatment].

Expanding Treatment Options for Breast Cancer

This study [highlights the importance of considering] [individualized treatment approaches] for [breast cancer]. The findings [emphasize the need for] [ongoing research] to [further evaluate the role of toremifene] and [optimize treatment strategies] for [premenopausal women with breast cancer]. This research is like a [desert oasis], [offering a wider range of treatment options] for [women facing this challenge].

Dr.Camel's Conclusion

This study [provides valuable insights] into [the comparative efficacy and safety] of [toremifene and tamoxifen] in [premenopausal women with breast cancer]. The findings [suggest that toremifene] may be [a promising alternative] to [tamoxifen], [offering a favorable risk-benefit profile]. This research is like a [desert caravan], [carrying the tools and knowledge] to [improve breast cancer treatment] and [enhance patient outcomes].

Date :
  1. Date Completed 2013-07-12
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22548922

DOI: Digital Object Identifier

PMC3503787

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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