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Comparison of metabolic effects of ziprasidone versus olanzapine treatment in patients with first-episode schizophrenia.

Author: ChenHong-Hui, FanXiaoduo, GaoKeming, GuoXiao-Feng, OuJian-Jun, WangJuan, WuRen-Rong, XuYi, ZhaoJing-Ping

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ziprasidone was associated with less adverse metabolic effects (weight gain, glucose, and lipid changes) compared to olanzapine in patients with first-episode schizophrenia. However, olanzapine was more effective in improving symptoms.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The objective of the study was to compare metabolic effects of ziprasidone versus olanzapine treatment in patients with first-episode schizophrenia. METHODS: In this 6-week, multicenter, open-label trial, 260 patients were randomly assigned to receive ziprasidone or olanzapine treatment ...See full text at original site
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引用元：
https://doi.org/10.1007/s00213-012-2850-6

データ提供：米国国立医学図書館（NLM）

Comparing Ziprasidone and Olanzapine: A Tale of Two Antipsychotics

Schizophrenia is a complex mental illness that affects millions worldwide. It's like a mental sandstorm that disrupts the delicate balance of thoughts and perceptions. This study compares the metabolic effects of two antipsychotic medications, ziprasidone and olanzapine, in patients with first-episode schizophrenia.

Evaluating the Metabolic Effects of Antipsychotics

The researchers conducted a 6-week trial to compare the metabolic effects of ziprasidone and olanzapine in patients with first-episode schizophrenia. This is like carefully observing the impact of different types of fertilizer on the desert ecosystem – they are trying to understand the effects of these medications on the body. The findings suggest that ziprasidone may have a more favorable metabolic profile than olanzapine, potentially leading to fewer weight gain and metabolic side effects.

The Importance of Choosing the Right Antipsychotic Medication

This study highlights the importance of carefully choosing the right antipsychotic medication for each patient. It’s like selecting the best route through the desert based on the available resources and the terrain. The study emphasizes the need to consider the potential metabolic effects of antipsychotics, particularly in patients with a history of weight gain or metabolic disorders.

Dr.Camel's Conclusion

The journey of treating schizophrenia is a challenging one, like navigating a vast and unpredictable desert. This study provides valuable insights into the metabolic effects of two antipsychotic medications, ziprasidone and olanzapine. It’s a reminder that the choice of medication should be tailored to the individual patient, taking into account their unique needs and potential risks. We continue to explore the desert of mental health, seeking better solutions for patients living with schizophrenia.

Date :
  1. Date Completed 2013-06-21
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

22926006

DOI: Digital Object Identifier

10.1007/s00213-012-2850-6

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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