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Paroxetine augmentation in patients with generalised social anxiety disorder, non-responsive to mirtazapine or placebo.

Author: SchruersKoen R J, SchuttersSara I J, Van VeenJ Frederieke, WestenbergHerman G M, van MegenHarold J G M

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Combining mirtazapine with paroxetine did not show a greater efficacy than paroxetine alone in treating social anxiety disorder (SAD). However, the combination treatment was associated with less sexual dysfunction compared to paroxetine alone.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The aim of the study was to investigate if combination of mirtazapine with paroxetine causes a greater therapeutic effect and less sexual side effects than paroxetine monotherapy in social anxiety disorder (SAD). METHODS: Twenty one patients with generalised SAD, non-responsive to a 12 ...See full text at original site
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引用元：
https://doi.org/10.1002/hup.1165

データ提供：米国国立医学図書館（NLM）

Social Anxiety Disorder: Seeking Relief Beyond Mirtazapine

Social anxiety disorder (SAD), a debilitating condition characterized by intense fear and anxiety in social situations, can significantly impair quality of life. This study investigated the efficacy of augmenting mirtazapine, an antidepressant, with paroxetine, another antidepressant, in patients with SAD who did not respond to mirtazapine or placebo.

Paroxetine Augmentation: Potential for Improved Treatment Outcomes

The study found that both paroxetine augmentation with mirtazapine and paroxetine augmentation with placebo resulted in significant reductions in social anxiety symptoms, with similar response rates. However, paroxetine augmentation with mirtazapine was associated with less sexual dysfunction than paroxetine alone. This suggests that paroxetine augmentation may offer a potential benefit for patients with SAD who do not respond to mirtazapine alone, particularly in terms of managing sexual side effects.

Navigating Treatment Options: Tailoring Therapy to Individual Needs

The study's findings provide valuable insights into treatment options for patients with SAD who do not respond to initial therapy. The study highlights the potential benefits of paroxetine augmentation, particularly in terms of reducing sexual dysfunction. The importance of tailoring treatment plans to individual patient needs and considering the potential for side effects remains crucial for effective management of SAD.

Dr. Camel's Conclusion

Just like a camel traversing a challenging desert landscape, researchers are constantly seeking new and improved ways to treat social anxiety disorder. This study, like a compass guiding us through the complexities of SAD treatment, highlights the potential benefits of augmenting mirtazapine with paroxetine. The study's findings underscore the importance of personalized care and tailoring treatment plans to individual patient needs, ensuring the most effective and tolerable treatment approach.

Date :
  1. Date Completed 2013-03-08
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

23055414

DOI: Digital Object Identifier

10.1002/hup.1165

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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