Effects of paroxetine: A Synthesis of Findings from 27 Studies

  1. Home
  2. Effects of paroxetine
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of paroxetine: A Synthesis of Findings from 27 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of paroxetine: A Synthesis of Findings from 27 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that has been found to be effective in treating a range of conditions, including stuttering, depression, and insomnia. For instance, 24 found that paroxetine significantly reduced stuttering-associated movements in the facial muscles, suggesting that it may be helpful for managing the physical symptoms of stuttering. However, 18 noted that paroxetine can disrupt sleep more than another SSRI, fluvoxamine, and that this sleep disruption can persist even after discontinuing the medication.

Regarding depression, multiple studies indicate paroxetine's efficacy. 3 found that paroxetine was more effective than imipramine in treating depression, demonstrating a better benefit-risk ratio. Further, 13 showed that paroxetine was as effective as imipramine in treating depressive symptoms, but it may have a faster and stronger effect on anxiety symptoms associated with depression.

Paroxetine is often preferred due to its lower side effect profile compared to other antidepressants. 6 found that paroxetine was significantly better than placebo in relieving depression and anxiety symptoms. 22 observed that paroxetine had a good safety profile in elderly patients, but four participants had to discontinue due to side effects.

Paroxetine has also been shown to be helpful for insomnia. 23 found that paroxetine combined with zolpidem was more effective in treating depression with insomnia than paroxetine alone.

Benefits and Risks

Benefit Summary

Paroxetine has been shown to be effective in treating a range of conditions, including stuttering, depression, and insomnia. It is often better tolerated than other antidepressants, with fewer side effects.

Risk Summary

Paroxetine can cause side effects such as sleep problems, memory problems, skin rashes, and gastrointestinal issues. These side effects may be more pronounced in older adults. While generally considered well-tolerated, individual patients may experience these side effects.

Comparison of Studies

Commonalities Across Studies

These studies consistently show that paroxetine has the potential to be effective in treating various conditions like stuttering, depression, and insomnia. These studies also agree that paroxetine is often better tolerated than other antidepressants.

Differences Across Studies

The studies varied in their findings on the severity of paroxetine's effects and the frequency of side effects. For example, 24 found that paroxetine significantly reduced stuttering-associated movements, while 18 found that it worsened sleep quality. These variations can be explained by differences in the research designs, participant characteristics, and dosage of paroxetine. Further research is needed to investigate these differences.

Consistency and Contradictions in the Results

While studies suggest paroxetine can be effective for a variety of conditions, there is some inconsistency in the extent of its effectiveness and the frequency of side effects. Notably, studies on paroxetine's effect on sleep provide conflicting results. Some studies show sleep improvement, while others demonstrate sleep disruption, highlighting the need for further research in this area.

Implications for Real-Life Applications

Paroxetine may be beneficial for treating conditions like stuttering, depression, and insomnia. However, these studies do not suggest that paroxetine is the most effective treatment for all patients. Before taking paroxetine, consulting a healthcare professional and choosing the appropriate treatment plan based on your specific symptoms is crucial. Remember that paroxetine can cause side effects. If you experience any side effects, consult with your doctor immediately.

Limitations of Current Research

The studies have limitations, including relatively small sample sizes, which may limit the generalizability of the findings. The long-term effects of paroxetine, including whether its benefits persist, are not fully understood. Additionally, research has not explored whether paroxetine affects different subtypes of stuttering, depression, or insomnia differently.

Future Directions for Research

Further research is needed to establish the full scope of paroxetine's effectiveness in treating various conditions, including stuttering, depression, and insomnia. Larger sample sizes and long-term follow-up studies are crucial to understand its long-term effects. Future research should also examine whether paroxetine has varying effects on different subtypes of these conditions. Additionally, investigating the effectiveness of paroxetine in combination with other therapies is essential.

Conclusion

Paroxetine is a medication that shows potential for treating conditions like stuttering, depression, and insomnia. While these studies suggest its effectiveness, they do not imply that paroxetine is the most effective treatment option for everyone. Consult with a healthcare professional to determine the appropriate treatment plan for your specific needs. These studies also highlight the importance of careful monitoring for side effects and the need for further research to fully understand the effects of paroxetine in different populations and for different conditions.

Literature analysis of 27 papers
Positive Content
24
Neutral Content
1
Negative Content
2
Article Type
26
1
0
3
27
1.

Cardiovascular effects of antidepressants: studies of paroxetine in healthy men and depressed patients.

Author: WarringtonS J, LewisY

Fewer cardiovascular side effects
No haemodynamic effects

Paroxetine was found to have similar efficacy to tricyclic antidepressants in treating depression, but with fewer cardiovascular side effects. It lacked any significant haemodynamic or electrophysiological effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

A review of the psychomotor effects of paroxetine.

Author: HindmarchI

Fewer side effects
Improved cognitive function

Paroxetine was found to have no detrimental effects on cognitive function or sleep quality in healthy volunteers and patients with major depressive illness, even when combined with alcohol. In contrast, amitriptyline and lorazepam produced significant impairment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Paroxetine and imipramine in the treatment of depressive patients in psychiatric practice.

Author: OhrbergS, ChristiansenP E, SeverinB, CalbergH, NilakantanB, BorupA, SøgaardJ, LarsenS B, LoldrupD, BahrB

Depression treatment
Well-tolerated
Weight gain

Paroxetine was more effective than imipramine in treating depression in 151 outpatients. Paroxetine also had fewer and less severe side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A placebo-controlled trial of paroxetine in the treatment of major depression.

Author: SmithW T, GlaudinV

Depression treatment
Reduced suicidal ideation

Paroxetine, a selective serotonin reuptake inhibitor, showed greater improvement than placebo in treating moderate to severe major depression, but the differences were not statistically significant. However, it was more effective in patients with long-term depression and resulted in a significant reduction in suicidal ideation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A 6-week, double-blind trial of paroxetine, imipramine, and placebo in depressed outpatients.

Author: FabreL F

Depression treatment
Few side effects

Paroxetine, a selective serotonin reuptake inhibitor, was significantly superior to placebo in treating major depression in a double-blind study. It was comparable to imipramine in efficacy, but had fewer anticholinergic side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Paroxetine in major depression: a double-blind trial with imipramine and placebo.

Author: CohnJ B, WilcoxC S

Anxiety relief
Depression relief
Few side effects

Paroxetine, a selective serotonin reuptake inhibitor, was superior to placebo in relieving depression and anxiety in patients with major depression. It was comparable to imipramine in efficacy but had fewer anticholinergic side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

A comparison of paroxetine, imipramine and placebo in depressed out-patients.

Author: DunbarG C, CohnJ B, FabreL F, FeighnerJ P, FieveR R, MendelsJ, ShrivastavaR K

Antidepressant effect
Side effects

Paroxetine and imipramine, antidepressants, were both significantly more effective than placebo in treating depression in 240 and 237 patients, respectively. Paroxetine was associated with fewer side effects and a possible earlier antidepressant effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. Danish University Antidepressant Group.

Author:

Antidepressant effect
Adverse reactions
Lack of effect
Mania

Clomipramine was more effective than paroxetine for treating major depressive disorder in a double-blind, randomized inpatient study. Clomipramine showed a significantly better therapeutic effect from the second week of treatment. However, it had more adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Paroxetine in the treatment of depression--a randomized comparison with amitriptyline.

Author: LaursenA L, MikkelsenP L, RasmussenS, le Fèvre HonoréP

Antidepressant
Dry mouth
Orthostatic dizziness

Paroxetine and amitriptyline showed no significant differences in overall antidepressant efficacy in 44 patients with depressive illnesses. Paroxetine had fewer instances of dry mouth and orthostatic dizziness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

EEG and blood level of the potential antidepressant paroxetine after a single oral dose to normal volunteers.

Author: McClellandG R, RaptopoulosP

Antidepressant effect

Paroxetine, a selective serotonin reuptake inhibitor, significantly altered the EEG in normal volunteers, decreasing delta and theta activity and increasing beta activity. These changes persisted 72 hours after treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

[Antidepressives and traffic safety].

Author: HerbergK W

Concentration problems
Loss of vigilance
Motor coordination problems
Reaction time problems

Paroxetine, an antidepressant, was found to have no significant effect on safety-relevant performance compared to placebo, while doxepin, another antidepressant, impaired vigilance, motor coordination, and concentration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

12.

A 12-week double-blind multi-centre study of paroxetine and imipramine in hospitalized depressed patients.

Author: ArminenS L, IkonenU, PulkkinenP, LeinonenE, MahlanenA, KoponenH, KourulaK, RyyppöJ, KorpelaV, LehtonenM L

Effective antidepressant
No side effects
Well tolerated
Reduced salivation

Paroxetine was as effective as imipramine in treating major depression with better tolerability, showing fewer side effects and a higher proportion of patients without side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

A study comparing paroxetine placebo and imipramine in depressed patients.

Author: FeighnerJ P, CohnJ B, FabreL F, FieveR R, MendelsJ, ShrivastavaR K, DunbarG C

Treats anxiety
Treats depression
Side effects

Paroxetine and imipramine were both effective for depression, but paroxetine may have a greater and earlier effect on anxiety. Paroxetine side effects were similar to other serotonin reuptake inhibitors, but different from those of imipramine, with fewer anticholinergic and cardiovascular symptoms and less premature withdrawal.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Double-blind multicenter study of paroxetine and amitriptyline in depressed inpatients.

Author: MöllerH J, BerzewskiH, EckmannF, GonzalvesN, KisslingW, KnorrW, ResslerP, RudolfG A, SteinmeyerE M, MagyarI

Antidepressant efficacy
Anticholinergic effects
Nausea

This study found that paroxetine, a selective serotonin reuptake inhibitor (SSRI) antidepressant, was equally effective as amitriptyline, a tricyclic antidepressant, at treating major depression. Both drugs had characteristic side effects, with paroxetine causing less anticholinergic effects but more nausea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

A comparison of paroxetine and placebo in depressed outpatients.

Author: DunbarG C, ClaghornJ L, KievA, RickelsK, SmithW T

Good tolerability
Improved depression symptoms
Common side effects

Paroxetine was effective in treating major depression and well-tolerated, with side effects similar to other serotonin reuptake inhibitors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Duplicate PublicationPublishing the same research/results in multiple journals/publications without proper disclosure/permission.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

A double-blind, multicentre study of paroxetine and maprotiline in major depression.

Author: SchnyderU, Koller-LeiserA

Comparable side effects
Similar efficacy

Paroxetine and maprotiline showed similar efficacy and side effect profiles in patients with major depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Paroxetine in the treatment of Chinese patients with depressive episode: a double-blind randomized comparison with imipramine.

Author: ChiuH J, HongC J, ChanC H

Effective for depression
Fewer anticholinergic effects
Anticholinergic effects
Impatience

Paroxetine was found to be as effective as imipramine in treating depression in Chinese patients, but with fewer anticholinergic adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: a home-based Nightcap evaluation during drug administration and withdrawal.

Author: SilvestriR, Pace-SchottE F, GershT, StickgoldR, SalzmanC, HobsonJ A

Sleep disruption

Paroxetine disrupted sleep more than fluvoxamine, and sleep disruption persisted into the withdrawal phase in healthy volunteers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors.

Author: SchmittJ A, KruizingaM J, RiedelW J

Improved verbal fluency
Impaired memory

Paroxetine, a serotonin reuptake inhibitor, impaired delayed recall in a word learning test at 20 and 40 mg doses. Sertraline, another serotonin reuptake inhibitor, did not affect word learning but improved performance on a verbal fluency task at 50 and 100 mg doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Cognitive and psychomotor effects of paroxetine and sertraline on healthy elderly volunteers.

Author: FurlanP M, KallanM J, Ten HaveT, PollockB G, KatzI, LuckiI

Improved cognitive function
Behavioral impairment

This study evaluated the cognitive and psychomotor effects of paroxetine and sertraline in healthy elderly volunteers. Results showed that paroxetine was associated with mild behavioral impairment, while sertraline was associated with mild and transient behavioral changes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

21.

Efficacy and tolerability of controlled-release and immediate-release paroxetine in the treatment of depression.

Author: GoldenRobert N, NemeroffCharles B, McSorleyPaul, PittsCornelius D, DubéEric M

Improved tolerability

Paroxetine controlled-release (CR) has been developed to improve general tolerability, particularly gastrointestinal tolerability, in patients taking antidepressants.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Tolerance and side-effects of paroxetine in elderly depressed patients.

Author: GhoseK

Improved mood
Well tolerated
Gastrointestinal symptoms
Skin rash

Paroxetine is an antidepressant that has fewer side effects than other antidepressants. A study of 12 elderly patients found that paroxetine was well-tolerated at doses of 15mg and 30mg per day. There were no significant changes in blood pressure, heart rate, or other measures of function. However, patients in the 30mg group showed a significant improvement in their symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

[Effects of paroxetine with or without zolpidem on depression with insomnia: a multi-center randomized comparative study].

Author: JiJian-Lin, LiuWen-Juan, ZhangNing, ChenZhi-Qing, ZhengAn-Lin, MeiQi-Yi, PanJi-Yang, ZhaoZhong-Xin, TaoMing, WangYu-Ping, WeiJing

Depression treatment
Insomnia treatment

Adding a hypnotic (zolpidem) to a selective serotonin reuptake inhibitor (SSRI) antidepressant (paroxetine) significantly enhanced the antidepressant's effects on depressive and anxiety symptoms in patients with depression and insomnia. The combination therapy resulted in greater improvements in sleep quality, depression severity, and anxiety levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

24.

Investigating the efficacy of paroxetine in developmental stuttering.

Author: BusanPierpaolo, BattagliniPiero Paolo, BorelliMassimo, EvaristoPasquale, MontiFabrizio, PelamattiGiovanna

Stuttering symptom management
None mentioned

Paroxetine may be useful in qualitative management of stuttering symptoms. Paroxetine administration shortened the cortical silent period (CSP) with no effect on motor thresholds, suggesting that it may act on the stuttering brain by diminishing intracortical inhibition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Effects of paroxetine on emotional functioning and treatment awareness: a 4-week randomized placebo-controlled study in healthy clinicians.

Author: BesnierNathalie, Cassé-PerrotCatherine, JouveElisabeth, NguyenNhan, LançonChristophe, FalissardBruno, BlinOlivier

Emotional Functioning Improvement

Paroxetine, an antidepressant, did not significantly impact emotional functioning in healthy individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Paroxetine augmentation in patients with generalised social anxiety disorder, non-responsive to mirtazapine or placebo.

Author: SchuttersSara I J, van MegenHarold J G M, Van VeenJ Frederieke, SchruersKoen R J, WestenbergHerman G M

Reduced sexual dysfunction

Combining mirtazapine with paroxetine did not show a greater efficacy than paroxetine alone in treating social anxiety disorder (SAD). However, the combination treatment was associated with less sexual dysfunction compared to paroxetine alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Comparative efficacies of fluoxetine and paroxetine in major depression across varying acute-phase treatment periods: a meta-analysis.

Author: WangYing, YuLehua, XieJing, ChenJianjun, WeiQianping

Effective for depression
Pseudoresistance

A meta-analysis of 17 studies comparing fluoxetine and paroxetine for depression found that paroxetine was more efficacious than fluoxetine in the 6-week subgroup, while fluoxetine was more efficacious than paroxetine in the 12-week subgroup. Both drugs displayed comparable efficacy in the 8/10-week subgroup. These findings suggest that the duration of acute-phase treatment is a significant factor in the efficacy of these antidepressants.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.