Effects of calcitonin salmon nasal spray: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that has been studied extensively for its efficacy and safety in treating depression and other mental health conditions. 6 found that paroxetine was significantly more effective than placebo in relieving depression. 12 showed that paroxetine had similar efficacy to imipramine, a tricyclic antidepressant, but with a better side effect profile. 1 provided evidence that paroxetine is less cardiotoxic compared to tricyclic antidepressants.

Paroxetine has also been shown to have a positive effect on anxiety symptoms associated with depression. 6 found that paroxetine was more effective than placebo in improving anxiety symptoms. 13 suggested that paroxetine might have a quicker and stronger effect on anxiety symptoms compared to imipramine.

Several studies have highlighted the safety and tolerability of paroxetine. 6 demonstrated that paroxetine had significantly fewer anticholinergic side effects than imipramine. 1 found that paroxetine had no significant effects on heart rate, blood pressure, or electrocardiogram in healthy men. 12 reported that paroxetine was well-tolerated and had fewer side effects compared to imipramine.

Benefits and Risks

Benefits Summary

Paroxetine has shown to be an effective treatment for major depression and anxiety symptoms. 6 , 12 , 13 demonstrated the effectiveness of paroxetine in reducing depressive symptoms. 6 , 13 suggested that paroxetine can also improve anxiety symptoms associated with depression.

Risks Summary

While generally considered safe, paroxetine can cause side effects in some individuals. 6 showed that paroxetine had fewer anticholinergic side effects than imipramine. However, other studies have reported gastrointestinal, neurological, or sexual side effects. 12 found that paroxetine was generally well-tolerated but individual responses to the medication can vary. It's important to consult with a doctor before taking paroxetine and to be aware of potential side effects.

Comparison Across Studies

Commonalities

Several studies consistently show that paroxetine is an effective treatment for major depression. 6 , 12 , 13 all concluded that paroxetine is effective in reducing depressive symptoms.

Differences

While the efficacy of paroxetine is consistent, some studies show variations in the degree of efficacy and side effects. 6 highlights fewer anticholinergic side effects with paroxetine compared to imipramine, while other studies report different types of side effects. 12 suggests better tolerability of paroxetine. These differences could be due to factors such as study populations, methodologies, and outcome measures.

Consistency and Contradictions

Research on paroxetine's efficacy in treating depression is generally consistent. 6 , 12 , 13 all support its effectiveness. However, inconsistencies exist regarding the magnitude of effectiveness and specific side effects. 6 highlights fewer anticholinergic side effects compared to imipramine, while other studies report different side effects. 12 suggests better tolerability. These discrepancies might be due to differences in research populations, methodologies, and outcome measures. Further research is required to clarify the precise efficacy and safety of paroxetine.

Practical Implications and Precautions

Paroxetine has shown to be a valuable treatment option for major depression and anxiety. 6 , 12 , 13 indicate its effectiveness. However, it's crucial to remember that individual responses to medication vary. When considering paroxetine, consulting with a doctor is essential to determine appropriate dosage and treatment plan. It's also vital to be aware of potential side effects and to discuss any concerns with your healthcare provider.

Limitations of Current Research

Research on paroxetine, despite being extensive, has some limitations. The studies mentioned, 6 , 12 , 13 , are relatively small in scale. Further research is needed to investigate long-term effects, potential interactions, and the optimal dosage for various patient groups.

Future Research Directions

Future research should focus on clarifying the precise efficacy and safety of paroxetine. 6 , 12 , 13 provide a good starting point, but larger, long-term studies are required to explore its effects across different patient populations and to establish optimal dosage regimens. Further research into the mechanisms of action of paroxetine and its interactions with other medications is also needed.

Conclusion

Paroxetine has proven to be a valuable treatment option for major depression and anxiety. 6 , 12 , 13 suggest its effectiveness. However, it's important to remember that medication responses vary. Before starting paroxetine, a consultation with a doctor is crucial to determine appropriate dosage and treatment plan. Additionally, staying informed about potential side effects and communicating any concerns with your doctor is vital.

Literature analysis of 27 papers
Positive Content
24
Neutral Content
1
Negative Content
2
Article Type
26
1
0
3
27
1.

Cardiovascular effects of antidepressants: studies of paroxetine in healthy men and depressed patients.

Author: WarringtonS J, LewisY

Fewer cardiovascular side effects
No haemodynamic effects

Paroxetine was found to have similar efficacy to tricyclic antidepressants in treating depression, but with fewer cardiovascular side effects. It lacked any significant haemodynamic or electrophysiological effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

A review of the psychomotor effects of paroxetine.

Author: HindmarchI

Fewer side effects
Improved cognitive function

Paroxetine was found to have no detrimental effects on cognitive function or sleep quality in healthy volunteers and patients with major depressive illness, even when combined with alcohol. In contrast, amitriptyline and lorazepam produced significant impairment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Paroxetine and imipramine in the treatment of depressive patients in psychiatric practice.

Author: OhrbergS, ChristiansenP E, SeverinB, CalbergH, NilakantanB, BorupA, SøgaardJ, LarsenS B, LoldrupD, BahrB

Depression treatment
Well-tolerated
Weight gain

Paroxetine was more effective than imipramine in treating depression in 151 outpatients. Paroxetine also had fewer and less severe side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A placebo-controlled trial of paroxetine in the treatment of major depression.

Author: SmithW T, GlaudinV

Depression treatment
Reduced suicidal ideation

Paroxetine, a selective serotonin reuptake inhibitor, showed greater improvement than placebo in treating moderate to severe major depression, but the differences were not statistically significant. However, it was more effective in patients with long-term depression and resulted in a significant reduction in suicidal ideation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A 6-week, double-blind trial of paroxetine, imipramine, and placebo in depressed outpatients.

Author: FabreL F

Depression treatment
Few side effects

Paroxetine, a selective serotonin reuptake inhibitor, was significantly superior to placebo in treating major depression in a double-blind study. It was comparable to imipramine in efficacy, but had fewer anticholinergic side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Paroxetine in major depression: a double-blind trial with imipramine and placebo.

Author: CohnJ B, WilcoxC S

Anxiety relief
Depression relief
Few side effects

Paroxetine, a selective serotonin reuptake inhibitor, was superior to placebo in relieving depression and anxiety in patients with major depression. It was comparable to imipramine in efficacy but had fewer anticholinergic side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

A comparison of paroxetine, imipramine and placebo in depressed out-patients.

Author: DunbarG C, CohnJ B, FabreL F, FeighnerJ P, FieveR R, MendelsJ, ShrivastavaR K

Antidepressant effect
Side effects

Paroxetine and imipramine, antidepressants, were both significantly more effective than placebo in treating depression in 240 and 237 patients, respectively. Paroxetine was associated with fewer side effects and a possible earlier antidepressant effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. Danish University Antidepressant Group.

Author:

Antidepressant effect
Adverse reactions
Lack of effect
Mania

Clomipramine was more effective than paroxetine for treating major depressive disorder in a double-blind, randomized inpatient study. Clomipramine showed a significantly better therapeutic effect from the second week of treatment. However, it had more adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Paroxetine in the treatment of depression--a randomized comparison with amitriptyline.

Author: LaursenA L, MikkelsenP L, RasmussenS, le Fèvre HonoréP

Antidepressant
Dry mouth
Orthostatic dizziness

Paroxetine and amitriptyline showed no significant differences in overall antidepressant efficacy in 44 patients with depressive illnesses. Paroxetine had fewer instances of dry mouth and orthostatic dizziness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

EEG and blood level of the potential antidepressant paroxetine after a single oral dose to normal volunteers.

Author: McClellandG R, RaptopoulosP

Antidepressant effect

Paroxetine, a selective serotonin reuptake inhibitor, significantly altered the EEG in normal volunteers, decreasing delta and theta activity and increasing beta activity. These changes persisted 72 hours after treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

[Antidepressives and traffic safety].

Author: HerbergK W

Concentration problems
Loss of vigilance
Motor coordination problems
Reaction time problems

Paroxetine, an antidepressant, was found to have no significant effect on safety-relevant performance compared to placebo, while doxepin, another antidepressant, impaired vigilance, motor coordination, and concentration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

12.

A 12-week double-blind multi-centre study of paroxetine and imipramine in hospitalized depressed patients.

Author: ArminenS L, IkonenU, PulkkinenP, LeinonenE, MahlanenA, KoponenH, KourulaK, RyyppöJ, KorpelaV, LehtonenM L

Effective antidepressant
No side effects
Well tolerated
Reduced salivation

Paroxetine was as effective as imipramine in treating major depression with better tolerability, showing fewer side effects and a higher proportion of patients without side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

A study comparing paroxetine placebo and imipramine in depressed patients.

Author: FeighnerJ P, CohnJ B, FabreL F, FieveR R, MendelsJ, ShrivastavaR K, DunbarG C

Treats anxiety
Treats depression
Side effects

Paroxetine and imipramine were both effective for depression, but paroxetine may have a greater and earlier effect on anxiety. Paroxetine side effects were similar to other serotonin reuptake inhibitors, but different from those of imipramine, with fewer anticholinergic and cardiovascular symptoms and less premature withdrawal.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Double-blind multicenter study of paroxetine and amitriptyline in depressed inpatients.

Author: MöllerH J, BerzewskiH, EckmannF, GonzalvesN, KisslingW, KnorrW, ResslerP, RudolfG A, SteinmeyerE M, MagyarI

Antidepressant efficacy
Anticholinergic effects
Nausea

This study found that paroxetine, a selective serotonin reuptake inhibitor (SSRI) antidepressant, was equally effective as amitriptyline, a tricyclic antidepressant, at treating major depression. Both drugs had characteristic side effects, with paroxetine causing less anticholinergic effects but more nausea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

A comparison of paroxetine and placebo in depressed outpatients.

Author: DunbarG C, ClaghornJ L, KievA, RickelsK, SmithW T

Good tolerability
Improved depression symptoms
Common side effects

Paroxetine was effective in treating major depression and well-tolerated, with side effects similar to other serotonin reuptake inhibitors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Duplicate PublicationPublishing the same research/results in multiple journals/publications without proper disclosure/permission.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

A double-blind, multicentre study of paroxetine and maprotiline in major depression.

Author: SchnyderU, Koller-LeiserA

Comparable side effects
Similar efficacy

Paroxetine and maprotiline showed similar efficacy and side effect profiles in patients with major depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Paroxetine in the treatment of Chinese patients with depressive episode: a double-blind randomized comparison with imipramine.

Author: ChiuH J, HongC J, ChanC H

Effective for depression
Fewer anticholinergic effects
Anticholinergic effects
Impatience

Paroxetine was found to be as effective as imipramine in treating depression in Chinese patients, but with fewer anticholinergic adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: a home-based Nightcap evaluation during drug administration and withdrawal.

Author: SilvestriR, Pace-SchottE F, GershT, StickgoldR, SalzmanC, HobsonJ A

Sleep disruption

Paroxetine disrupted sleep more than fluvoxamine, and sleep disruption persisted into the withdrawal phase in healthy volunteers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors.

Author: SchmittJ A, KruizingaM J, RiedelW J

Improved verbal fluency
Impaired memory

Paroxetine, a serotonin reuptake inhibitor, impaired delayed recall in a word learning test at 20 and 40 mg doses. Sertraline, another serotonin reuptake inhibitor, did not affect word learning but improved performance on a verbal fluency task at 50 and 100 mg doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Cognitive and psychomotor effects of paroxetine and sertraline on healthy elderly volunteers.

Author: FurlanP M, KallanM J, Ten HaveT, PollockB G, KatzI, LuckiI

Improved cognitive function
Behavioral impairment

This study evaluated the cognitive and psychomotor effects of paroxetine and sertraline in healthy elderly volunteers. Results showed that paroxetine was associated with mild behavioral impairment, while sertraline was associated with mild and transient behavioral changes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

21.

Efficacy and tolerability of controlled-release and immediate-release paroxetine in the treatment of depression.

Author: GoldenRobert N, NemeroffCharles B, McSorleyPaul, PittsCornelius D, DubéEric M

Improved tolerability

Paroxetine controlled-release (CR) has been developed to improve general tolerability, particularly gastrointestinal tolerability, in patients taking antidepressants.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Tolerance and side-effects of paroxetine in elderly depressed patients.

Author: GhoseK

Improved mood
Well tolerated
Gastrointestinal symptoms
Skin rash

Paroxetine is an antidepressant that has fewer side effects than other antidepressants. A study of 12 elderly patients found that paroxetine was well-tolerated at doses of 15mg and 30mg per day. There were no significant changes in blood pressure, heart rate, or other measures of function. However, patients in the 30mg group showed a significant improvement in their symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

[Effects of paroxetine with or without zolpidem on depression with insomnia: a multi-center randomized comparative study].

Author: JiJian-Lin, LiuWen-Juan, ZhangNing, ChenZhi-Qing, ZhengAn-Lin, MeiQi-Yi, PanJi-Yang, ZhaoZhong-Xin, TaoMing, WangYu-Ping, WeiJing

Depression treatment
Insomnia treatment

Adding a hypnotic (zolpidem) to a selective serotonin reuptake inhibitor (SSRI) antidepressant (paroxetine) significantly enhanced the antidepressant's effects on depressive and anxiety symptoms in patients with depression and insomnia. The combination therapy resulted in greater improvements in sleep quality, depression severity, and anxiety levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

24.

Investigating the efficacy of paroxetine in developmental stuttering.

Author: BusanPierpaolo, BattagliniPiero Paolo, BorelliMassimo, EvaristoPasquale, MontiFabrizio, PelamattiGiovanna

Stuttering symptom management
None mentioned

Paroxetine may be useful in qualitative management of stuttering symptoms. Paroxetine administration shortened the cortical silent period (CSP) with no effect on motor thresholds, suggesting that it may act on the stuttering brain by diminishing intracortical inhibition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Effects of paroxetine on emotional functioning and treatment awareness: a 4-week randomized placebo-controlled study in healthy clinicians.

Author: BesnierNathalie, Cassé-PerrotCatherine, JouveElisabeth, NguyenNhan, LançonChristophe, FalissardBruno, BlinOlivier

Emotional Functioning Improvement

Paroxetine, an antidepressant, did not significantly impact emotional functioning in healthy individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Paroxetine augmentation in patients with generalised social anxiety disorder, non-responsive to mirtazapine or placebo.

Author: SchuttersSara I J, van MegenHarold J G M, Van VeenJ Frederieke, SchruersKoen R J, WestenbergHerman G M

Reduced sexual dysfunction

Combining mirtazapine with paroxetine did not show a greater efficacy than paroxetine alone in treating social anxiety disorder (SAD). However, the combination treatment was associated with less sexual dysfunction compared to paroxetine alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Comparative efficacies of fluoxetine and paroxetine in major depression across varying acute-phase treatment periods: a meta-analysis.

Author: WangYing, YuLehua, XieJing, ChenJianjun, WeiQianping

Effective for depression
Pseudoresistance

A meta-analysis of 17 studies comparing fluoxetine and paroxetine for depression found that paroxetine was more efficacious than fluoxetine in the 6-week subgroup, while fluoxetine was more efficacious than paroxetine in the 12-week subgroup. Both drugs displayed comparable efficacy in the 8/10-week subgroup. These findings suggest that the duration of acute-phase treatment is a significant factor in the efficacy of these antidepressants.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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