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Comparison of prasugrel and clopidogrel reloading on high platelet reactivity in clopidogrel-loaded patients undergoing percutaneous coronary intervention (PRAISE-HPR): a study protocol for a prospective randomized controlled clinical trial.

Author: KimMoo Hyun, LeeDong-Hyun, LeeMichael S, ParkJong Sung, ParkKyungil, ParkTae-Ho, SeoJeong-Min, ZhangHong-Zhe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prasugrel reloading is hypothesized to be more effective than clopidogrel reloading in patients with high on-treatment platelet reactivity (HPR) after an initial loading dose of clopidogrel.
Paper Details　
Original Abstract of the Article :
Patients with reduced responsiveness to clopidogrel often have diminished platelet inhibition, a factor associated with increased rates of major adverse cardiovascular events. Clinical trials that have focused on reducing high on-treatment platelet reactivity (HPR) with an additional loading dose of...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598796/

データ提供：米国国立医学図書館（NLM）

A Race Against Time: Comparing Prasugrel and Clopidogrel for High Platelet Reactivity

This research explores the challenges of managing high platelet reactivity (HPR), a condition that can increase the risk of blood clots and cardiovascular events. Think of this research as a race against time through a desert landscape, where the goal is to prevent a dangerous sandstorm. The researchers compare the effectiveness of two drugs, prasugrel and clopidogrel, in reducing HPR in patients undergoing percutaneous coronary intervention (PCI).

A Comparative Study of Antiplatelet Medications

This research compares the effectiveness of prasugrel and clopidogrel in reducing HPR, much like comparing two different types of camel for traversing a desert. The authors hypothesize that prasugrel, a newer drug, might be more effective in lowering HPR compared to clopidogrel, offering a faster and more reliable way to prevent a sandstorm.

Navigating the Desert of Cardiovascular Risk

This research offers valuable insights into the management of HPR, providing clinicians with a better understanding of which medications may be most effective in reducing cardiovascular risk. Imagine a traveler carefully selecting their camel, choosing the one best suited for the terrain and potential hazards. This research helps doctors make informed decisions about which antiplatelet medication to use for their patients, ensuring the safest and most effective journey.

Dr. Camel's Conclusion

This research is like a journey across a desert landscape, where the goal is to reach the other side safely and efficiently. The authors' findings offer valuable insights into the effectiveness of different antiplatelet medications, helping clinicians choose the right strategy for managing HPR and reducing cardiovascular risk. This research is a reminder that even in the most treacherous environments, careful planning and the right tools can make all the difference.
Date :
  1. Date Completed 2013-09-09
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23448344

DOI: Digital Object Identifier

PMC3598796

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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