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Difference in remission in a Chinese population with anxious versus nonanxious treatment-resistant depression: a report of OPERATION study.

Author: CaoLan, ChenJun, FangYiru, HongWu, PengDaihui, WuZhiguo, YuanChengmei, ZhangChen

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Anxious depression is associated with poorer treatment outcomes in patients with treatment-resistant depression. Remission rates were significantly lower and adverse event frequency was significantly greater in patients with anxious depression compared to those with non-anxious depression.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A secondary analysis was conducted to compare treatment outcomes for anxious depression and nonanxious depression in previous published OPERATION trials of a variety of antidepressants and augmentation strategies for patients with treatment-resistant depression (TRD). METHODS: A total o...See full text at original site
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引用元：
https://doi.org/10.1016/j.jad.2013.03.012

データ提供：米国国立医学図書館（NLM）

Anxiety and Treatment-Resistant Depression in China

This research dives into the world of [treatment-resistant depression (TRD)] in China, specifically focusing on the impact of anxiety on treatment outcomes. Like a camel navigating a challenging desert, patients with anxious TRD faced a tougher journey to remission compared to those without anxiety. The study used a [secondary analysis of data from OPERATION trials] to investigate this phenomenon. They found that nearly 70% of participants had anxious depression, and those individuals had significantly lower remission rates and higher rates of adverse events. This underscores the crucial role of anxiety in complicating the path to recovery for individuals with TRD. The study highlights the importance of addressing anxiety alongside depression for more effective treatment, especially in China where co-morbidity diagnoses can be challenging.

Anxiety: A Barrier to Recovery

The findings reveal that anxiety is a significant factor in the effectiveness of depression treatment. It acts as a stumbling block on the road to recovery, making the journey longer and more difficult. This is particularly important to consider in China, where co-morbidity diagnoses can be more challenging. This research reinforces the idea that anxiety is not just a co-occurring symptom but plays a significant role in the overall treatment journey.

A Holistic Approach is Key

Treating depression effectively often requires a multifaceted approach that goes beyond just addressing the core symptoms. Like the desert's ecosystem, where various elements are interconnected, the human mind and body are also interconnected. This study reminds us of the importance of considering the interplay of anxiety and depression when providing treatment. A holistic approach that addresses both aspects can pave the way for a smoother and more successful recovery journey for patients.

Dr.Camel's Conclusion

This study is like a compass guiding us through the complex landscape of treatment-resistant depression. It underscores the crucial role of anxiety in TRD and its impact on treatment outcomes. The findings suggest that a holistic approach to treatment, considering both anxiety and depression, is essential for achieving optimal outcomes.

Date :
  1. Date Completed 2014-05-12
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

23570952

DOI: Digital Object Identifier

10.1016/j.jad.2013.03.012

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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