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Antihypertensive effects of beta-blockers administered once daily: 24-hour measurements.

Author: CheungD G, GraettingerW F, NeutelJ M, SchnaperH, WeberM A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Acebutolol provided longer-lasting blood pressure reduction compared to atenolol, with a greater effect in the final 6 hours of the dosing interval.
Paper Details　
Original Abstract of the Article :
Whole-day automated ambulatory blood pressure (BP) monitoring was used to assess the duration of the antihypertensive actions of the beta-blockers atenolol (50 to 100 mg; n = 20) and acebutolol (400 to 800 mg; n = 19) each given once daily at 9 AM. When compared with its pretreatment 24-hour average...See full text at original site
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引用元：
https://doi.org/10.1016/0002-8703(90)90174-v

データ提供：米国国立医学図書館（NLM）

Once-Daily Beta-Blockers: A Comprehensive Analysis of Antihypertensive Effects

This study used 24-hour ambulatory blood pressure (BP) monitoring to assess the duration of the antihypertensive effects of atenolol and acebutolol, both beta-blockers administered once daily. The results revealed that both drugs effectively lowered BP throughout the day, with acebutolol demonstrating a longer-lasting effect compared to atenolol. These findings provide valuable insights into the pharmacokinetic properties of these commonly prescribed antihypertensive medications.

Choosing the Right Beta-Blocker for You

The study suggests that acebutolol, a beta-blocker with a longer duration of action, might be more suitable for patients requiring sustained BP control. This information is vital for clinicians in selecting the most appropriate medication for their patients' individual needs. However, it is crucial to consult with a healthcare professional before making any changes to medication regimens.

Understanding the Dynamics of Beta-Blockers

This study delves into the intricacies of beta-blocker pharmacokinetics, highlighting the differences in their duration of action. These insights are essential for physicians in making informed decisions about medication selection and dosage, ensuring optimal therapeutic outcomes for patients. It is a reminder that the choice of medication should be tailored to the individual patient's needs and characteristics.

Dr.Camel's Conclusion

This study sheds light on the antihypertensive effects of once-daily beta-blockers. The results demonstrate the efficacy of both atenolol and acebutolol, with acebutolol exhibiting a longer-lasting effect. These findings offer valuable insights for clinicians in selecting the most appropriate beta-blocker for individual patients, ensuring optimal blood pressure control and promoting overall cardiovascular health.

Date :
  1. Date Completed 1990-08-01
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

2360502

DOI: Digital Object Identifier

10.1016/0002-8703(90)90174-v

SNS
PICO Info
in preparation
Languages

English

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