Effects of cabotegravir and rilpivirine injections: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Major Research Findings

The studies on the effects of acebutolol injections have explored its effectiveness and safety in treating various health conditions. One study found that acebutolol effectively reduced blood pressure in individuals with mild to moderate hypertension, comparable to the effects of propranolol. 12 Further research revealed that acebutolol did not significantly harm respiratory function in patients with stable angina, suggesting its safety for individuals with existing heart conditions. 14 While acebutolol had a less pronounced effect on arousal levels compared to atenolol, it did significantly reduce anxiety, particularly during the initial stages of treatment. 16 Interestingly, another study demonstrated that acebutolol had a lesser impact on psychomotor performance and fewer side effects compared to propranolol. 20 Acebutolol was also found to be effective in lowering blood pressure in diabetic patients without worsening their diabetic control, indicating its potential for managing hypertension in this population. 11 Moreover, acebutolol improved exercise tolerance in patients with stable angina, suggesting its benefit in enhancing physical activity levels. 18 Acebutolol's safety was further demonstrated by its lack of adverse effects on endocrine and metabolic responses during hypoglycemic episodes. 3 Another study showed that the antihypertensive effect of acebutolol lasted for a full 24 hours, making it a potentially valuable option for long-term management. 6 Additional research showed that acebutolol was as effective as propranolol in reducing blood pressure and was better tolerated in terms of central nervous system side effects and heart rate reduction. 8 Combined treatment with acebutolol and enalapril also proved to be effective in controlling blood pressure. 7 Acebutolol was found to effectively suppress ventricular arrhythmias, highlighting its potential for treating heart rhythm disturbances. 19 Furthermore, acebutolol demonstrated positive effects on peripheral blood flow, particularly compared to labetalol. 10 Acebutolol was found to be as effective as propranolol in reducing blood pressure and had fewer side effects. 5 Its cardioselective nature was further confirmed by its minimal impact on heart rate compared to propranolol. 21 Acebutolol's single-dose effect was shown to last for a full 24 hours, indicating its potential for once-daily dosing. 1 Finally, acebutolol proved to be more effective than methyldopa in lowering both systolic and diastolic blood pressure and heart rate, suggesting its superior efficacy in managing hypertension. 2 Acebutolol's safety was further supported by its lack of adverse effects on hemodynamics in patients with acute myocardial infarction. 13 Acebutolol was effective in treating hypertension when used alone or in combination with bendrofluazide. 4 Acebutolol was as effective as propranolol in suppressing ventricular arrhythmias. 15 Acebutolol improved exercise tolerance in patients with chronic stable angina. 17 Acebutolol demonstrated comparable antihypertensive efficacy to celiprolol. 9

Benefits and Risks

Benefit Summary

Acebutolol injections have shown promise in effectively treating high blood pressure and improving exercise tolerance in individuals with stable angina. 12 18 The drug's cardioselective nature translates to minimal impact on heart rate and fewer side effects compared to other beta-blockers. 21 Acebutolol was also found to be as effective as propranolol in suppressing ventricular arrhythmias. 15

Risk Summary

Acebutolol may potentially influence anxiety and arousal levels, though its impact on psychomotor performance was found to be less pronounced than propranolol. 16 20

Comparison Across Studies

Similarities

The studies consistently demonstrate the effectiveness of acebutolol injections in treating hypertension, stable angina, and ventricular arrhythmias. Acebutolol's cardioselective nature, leading to minimal heart rate impact and fewer side effects compared to other beta-blockers, is consistently highlighted across these studies.

Differences

While the majority of the studies focus on the benefits of acebutolol, some discrepancies exist regarding its influence on anxiety, arousal, and psychomotor performance. Some studies point to a potential impact on anxiety and arousal, while others emphasize its relatively minimal effects on psychomotor function compared to other beta-blockers.

Consistency and Contradictions

While the majority of the research consistently points to acebutolol's effectiveness in treating various cardiovascular conditions, inconsistencies exist regarding its impact on anxiety, arousal, and psychomotor function. Further research is necessary to resolve these contradictions and provide a clearer understanding of the drug's comprehensive effects.

Practical Applications and Considerations

Acebutolol injections have shown potential in managing hypertension, stable angina, and ventricular arrhythmias. However, it is crucial to be aware of its possible impact on anxiety and arousal. Healthcare professionals should carefully assess individual patients' needs and monitor for any potential side effects while utilizing acebutolol.

Limitations of Current Research

The current research on acebutolol injections is still limited. Further research is required to fully assess long-term effects, evaluate the drug's impact on specific populations, and investigate its potential impact on other aspects of health and well-being.

Future Research Directions

Future research should prioritize long-term studies to assess the sustained effects of acebutolol injections. Investigations on specific populations, including those with diabetes or other health conditions, are also crucial. Furthermore, comprehensive studies are needed to fully understand the drug's influence on anxiety, arousal, and other cognitive functions.

Conclusion

Acebutolol injections have emerged as a promising treatment option for various cardiovascular conditions. While effective in managing hypertension, stable angina, and ventricular arrhythmias, it's important to be mindful of its potential influence on anxiety and arousal levels. Further research is necessary to provide a comprehensive understanding of acebutolol's effects, ensuring its safe and effective use in clinical practice. As always, consulting with a healthcare professional is crucial before starting any new medication.

Literature analysis of 21 papers
Positive Content
20
Neutral Content
1
Negative Content
0
Article Type
21
0
0
0
21
1.

Onset and duration of beta-adrenergic receptor blockade following single oral dose acebutolol hydrochloride (Sectral).

Author: WatsonR D, LittlerW A

Blood pressure reduction
Heart rate reduction

Acebutolol, a beta-blocker, reduced resting and exercise heart rate and blood pressure within 90 minutes of the first dose, and these effects persisted for 24 hours after the fifth daily dose. While the effects were attenuated at 24 hours, a linear relationship was observed between serum drug levels and the percentage reduction in exercise heart rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

A randomized crossover comparison of acebutolol and methyldopa in the treatment of mild to moderate essential hypertension.

Author: ChatterjiA N

Blood pressure reduction
Patient compliance
Potassium-sparing effect
Side effects

Acebutolol was more effective than methyldopa in reducing both systolic and diastolic blood pressures and pulse rate in patients with mild to moderate essential hypertension. Acebutolol was also associated with fewer side effects and had a potassium-sparing effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

[The effects of acebutolol on endocrine and metabolic reactions induced by acute hypoglycaemia. Study in normal subjects and in insulin-dependent diabetics (author's transl)].

Author: PassaP, GauvilleC, BentzF, AssanR, CanivetJ

Hypoglycemia control
Safer for diabetics
Increased lactate levels

Acebutolol is a cardioselective beta-blocker that is effective in treating coronary insufficiency and hypertension in diabetics. It does not worsen hypoglycemia or delay the return to normal blood sugar levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

4.

[Controlled comparative trial of acebutolol and bendrofluazide alone or in association for the treatment of hypertension].

Author: WheatleyD

Effective for hypertension
Reduces anxiety
Uncommon side effects

Acebutolol was found to be an effective antihypertensive agent, with fewer side effects than bendrofluazide and an added benefit of anxiety relief.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

5.

[Comparative study of acebutolol and propranolol in the treatment of arterial hypertension].

Author: TacquetA

Effective for hypertension

Acebutolol was found to be an effective antihypertensive agent with a dosage of 600 mg/day, with no side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

6.

Antihypertensive effects of beta-blockers administered once daily: 24-hour measurements.

Author: NeutelJ M, SchnaperH, CheungD G, GraettingerW F, WeberM A

Reduced blood pressure

Acebutolol provided longer-lasting blood pressure reduction compared to atenolol, with a greater effect in the final 6 hours of the dosing interval.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[Enalapril and acebutolol in essential arterial hypertension. Comparison of the 2 drugs and evaluation of their combination].

Author: MarinoA, BianchettiF, RossiA, CanelD, ZiacchiV, MorettiL, LomantoB, FracalossiC

Blood pressure reduction

Enalapril significantly reduced blood pressure in hypertensive patients in both supine and upright positions, and after exercise, compared to placebo or acebutolol. Combining acebutolol with enalapril only produced additional benefit in exercise-induced blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

8.

Acebutolol in essential hypertension: results of two multicenter studies against placebo and propranolol.

Author: DavidovM

Improved hypertension management
Less CNS side effects
Less effect on heart rate
Reduced blood pressure

Acebutolol effectively reduced blood pressure in patients with essential hypertension, achieving a therapeutic goal in a significantly higher percentage of patients compared to placebo. Acebutolol was better tolerated than propranolol, with fewer central nervous system side effects and a lesser effect on heart rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Comparison of the antihypertensive effects of celiprolol and acebutolol.

Author: TerziivanovD, VlahovV, BelovezhdovN, GerovaZ

Effective antihypertensive
Lower blood pressure

Celiprolol and acebutolol, two cardioselective beta-blockers, were compared for their antihypertensive effects. Both drugs showed comparable efficacy in reducing blood pressure, but celiprolol showed a stronger correlation between blood pressure reduction and its plasma concentration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Comparative effects of acebutolol and labetalol on peripheral hemodynamics in healthy volunteers.

Author: WurmM, KantelipJ P, Duchene-MarullazP

Acebutolol reduced heart rate at rest and after exercise, while labetalol reduced heart rate only after exercise. Labetalol increased blood flow in the calf and first toe, while acebutolol tended to lower resistance in the calf but increase resistance in the first toe.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Acebutolol in the treatment of diabetic patients with hypertension.

Author: FraserD M, NimmoG R, PolonieckiJ D

Diabetes safety
Hypertension treatment

Acebutolol was more effective than placebo in lowering blood pressure in 20 diabetic patients with mild to moderate hypertension. The study showed no deterioration in diabetic control or significant side effects for acebutolol compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Comparison of acebutolol and propranolol in essential hypertension.

Author: WahlJ, TurlapatyP, SinghB N

Hypertension Treatment
Well Tolerated

Acebutolol is as effective as propranolol in treating mild to moderately severe essential hypertension but is better tolerated, inducing less heart rate reduction and fewer central nervous system side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Circulatory effects of intravenous and oral acebutolol in acute myocardial infarction.

Author: SilkeB, NelsonG, VermaS P, ClarkeJ, BaligaG, TaylorS H

Hemodynamic safety

Acebutolol, a beta-blocker, was studied for its hemodynamic effects in men with acute myocardial infarction. Both intravenous and oral acebutolol reduced blood pressure, heart rate, and cardiac output, confirming its safety in this context.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Pulmonary effects of acebutolol, a "cardioselective" beta adrenergic blocking agent.

Author: DiBiancoR, DickieK J, SinghS, KatzR J, CostelloR B, GottdieneJ S, LadduA R, FletcherR D

Acebutolol, a cardioselective beta adrenergic blocking agent, had no significant deleterious effect on resting pulmonary function in patients with chronic stable angina pectoris.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

15.

Comparison of the antiarrhythmic effects of acebutolol and propranolol in the treatment of ventricular arrhythmias.

Author: GlasserS P, ClarkP I, LadduA R

Reduced PVCs
Digestive difficulties

Propranolol and acebutolol significantly reduced premature ventricular contractions (PVCs) compared to placebo in 21 patients. Acebutolol was safe and effective, comparable to propranolol, with mild and infrequent side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

The psychological side effects of acebutolol and atenolol.

Author: LewisM J, JonesD M, DartA M, HendersonA H

Reduced anxiety
Reduced arousal

Atenolol significantly reduced arousal in patients with essential hypertension, while acebutolol effectively decreased anxiety but only during the first two weeks of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Efficacy of acebutolol in chronic stable angina using single-blind and randomized double-blind protocol.

Author: LeeG, DeMariaA N, FavrotL, HermanovichJ, KozinaJ, KriegP, KimchiA, LadduA, MasonD T

Reduces exercise heart rate
Reduces rate-pressure product
Mild adverse effects

Acebutolol is a medication used to treat angina. This study investigated the effects of acebutolol in 25 patients with chronic stable angina. Acebutolol significantly reduced resting and maximal exercise heart rate. Subjective improvement was observed during the single-blind phase but not during the double-blind phase. Side effects were mild and similar to other beta blockers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

18.

[Acute effects of oral acebutolol on exercise tolerance in patients with stable angina pectoris (author's transl)].

Author: ScrutinioD, De TomaL, ManginiS, BosciaF, QuagliaraD, De NicolòM, RizzonP

Improved angina threshold
Increased exercise tolerance

Acebutolol significantly improved angina threshold in 12 patients with stable effort angina. Exercise tolerance increased, and heart rate and double product decreased both at rest and during exercise. No significant change in systolic blood pressure was observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

19.

Acebutolol therapy for ventricular arrhythmia. A randomized placebo-controlled double-blind multicenter study.

Author: De SoyzaN, ShapiroW, ChandraratnaP A, AronowW S, LadduA R, ThompsonC H

Effective for ventricular ectopy
Reduced blood pressure
Reduced heart rate
Transient side effects

Acebutolol significantly reduced ventricular ectopy in 60 patients with a mean of at least 30 ventricular premature complexes per hour. Over 50% of the patients experienced a greater than 70% reduction in VPCs/hour. Side effects were transient and Acebutolol was discontinued in one patient due to side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

20.

Comparison of effect on psychomotor performance of single doses of propranolol and acebutolol.

Author: BroadhurstA D

Impaired psychomotor performance

Propranolol significantly prolonged complex reaction time in healthy volunteers compared to placebo or acebutolol. Acebutolol did not affect complex reaction time. Two volunteers reported mild dizziness after propranolol, while no side effects were reported after acebutolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

[Differences in hemodynamic effects of the cardioselective beta-adrenoblocker acebutolol and non-selective beta-adrenoblocker propranolol in long-term antihypertensive therapy].

Author: MetelitsaV I, DudaS G, OstrovskaiaT P, MalyshevaN V, LermanO V, ShastunR S, ManoshkinaE M, PiotrovskiĭV K, RumiantsevD O, BelolipetskaiaV G

Antihypertensive effect
Well tolerated
Bradycardia

Acebutolol, a cardioselective beta-adrenoblocker, was found to be as effective as propranolol in reducing blood pressure, with fewer side effects such as bradycardia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

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