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Therapies for active rheumatoid arthritis after methotrexate failure.

Author: , AhluwaliaVandana, AnisAslam H, BrophyMary, CannellaAmy C, KeystoneEdward, KunkelGary, LeathermanSarah, LewRobert A, MikulsTed R, O'DellJames R, PhibbsCiaran S, TaylorThomas H, WarrenStuart R

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, American Recovery and Reinvestment ActResearch and economic activity support funds provided under the American Recovery and Reinvestment Act of 2009.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

There are limited studies that directly compare conventional treatments (combinations of medications) with biologic drugs in rheumatoid arthritis (RA) patients whose disease isn't adequately controlled by methotrexate, a common situation in managing RA.
Paper Details　
Original Abstract of the Article :
Few blinded trials have compared conventional therapy consisting of a combination of disease-modifying antirheumatic drugs with biologic agents in patients with rheumatoid arthritis who have active disease despite treatment with methotrexate--a common scenario in the management of rheumatoid arthrit...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa1303006

データ提供：米国国立医学図書館（NLM）

The Quest for Effective Rheumatoid Arthritis Treatment

In the vast desert of rheumatoid arthritis (RA) research, finding effective therapies is an ongoing journey. This study tackles a common dilemma in RA management: what to do when the widely used drug, methotrexate, fails to tame the disease? The researchers conducted a study to compare conventional therapy with biologic agents in patients with active RA despite methotrexate treatment. The study highlights the need for effective strategies to manage RA, especially when conventional treatments fall short.

The Importance of Effective Treatment Options

This study underscores the critical need for effective treatments for RA. When methotrexate fails to bring the disease under control, patients require alternative options. This study provides valuable insights into the potential benefits of biologic agents for patients who are not responding to conventional therapies.

Navigating the Desert of RA Treatment Options

The study emphasizes the importance of individualizing treatment strategies for RA. Just like in a desert where each oasis offers unique resources, patients require tailored treatment approaches. This study points to the potential of biologic agents as a valuable resource for patients who haven’t found relief from conventional therapies.

Dr. Camel's Conclusion

This research, like a refreshing oasis in the desert of RA research, sheds light on the need for more effective treatment options when methotrexate fails. Biologic agents might be the answer for many patients, but further research is needed to determine the best approach for each individual. Remember, just like the desert is a diverse landscape, RA patients are unique individuals who require personalized care.

Date :
  1. Date Completed 2013-08-02
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

23755969

DOI: Digital Object Identifier

10.1056/NEJMoa1303006

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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