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The effects of amlodipine and S(-)-amlodipine on vascular endothelial function in patients with hypertension.

Author: DingMei, HeYuquan, LiBing, NiLujia, SiDaoyuan, YangChunyan, YangPing

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

S(-)-amlodipine, an enantiomer of amlodipine, showed similar effects on vascular endothelial function in hypertensive patients compared to amlodipine. This study further investigated the underlying mechanisms of action in cell culture.
Paper Details　
Original Abstract of the Article :
Amlodipine has been shown to improve vascular endothelial function in hypertensive patients, but whether S(-)-amlodipine has a similar effect remains controversial. This study compared the effects of amlodipine and S(-)-amlodipine on vascular endothelial function in hypertensive patients and investi...See full text at original site
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引用元：
https://doi.org/10.1093/ajh/hpt138

データ提供：米国国立医学図書館（NLM）

Amlodipine and Vascular Endothelial Function

Hypertension, or high blood pressure, can be like a relentless desert wind, putting strain on our blood vessels. This study investigates the effects of amlodipine, a commonly prescribed antihypertensive medication, on vascular endothelial function. Endothelial cells line our blood vessels and play a crucial role in maintaining healthy blood flow.

A Closer Look at Amlodipine's Effects

The study aims to compare the effects of amlodipine and its active enantiomer, S(-)-amlodipine, on vascular endothelial function in hypertensive patients. The researchers also explore potential mechanisms of action at the cellular level. This research adds to our understanding of how amlodipine works and its potential benefits for managing hypertension.

Maintaining Cardiovascular Health

This study underscores the importance of understanding the intricate mechanisms of action of antihypertensive medications. It highlights the potential benefits of amlodipine for maintaining healthy blood vessels and protecting against cardiovascular disease. It's crucial to consult with a healthcare professional to discuss the appropriate treatment options for managing hypertension and ensure optimal cardiovascular health.

Dr.Camel's Conclusion

This research delves into the complexities of vascular health, exploring the intricacies of amlodipine and its effects on blood vessel function. This knowledge is essential for optimizing treatment for hypertension, ensuring that our vessels remain strong and resilient like a desert camel navigating harsh conditions.

Date :
  1. Date Completed 2014-07-28
  2. Date Revised 2013-12-04
Further Info :

Pubmed ID

23959544

DOI: Digital Object Identifier

10.1093/ajh/hpt138

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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