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Pharmacologic control of uterine contractility. In vitro human and in vivo monkey studies.

Author: HarbertG M, JohnsonW L, MartinC B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Prostaglandin antagonists indomethacin and fenoprofen showed depressant activity on human uterine activity in vitro. Fenoprofen was effective in reducing uterine contractility without serious maternal or fetal side effects.
Paper Details　
Original Abstract of the Article :
The exact cause and mechanism of the onset of labor are unknown but the theories are many. There is considerable evidence that prostaglandins are potent stimulants of uterine activity and may play a role in the onset of labor. Prostaglandin release may be the natural mediator of uterine contractions...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0002-9378(16)33437-8

データ提供：米国国立医学図書館（NLM）

Controlling Uterine Contractility: A Quest for Safer Premature Labor Management

Premature labor is a significant complication during pregnancy, potentially leading to serious consequences for both mother and child. This research explores the potential of pharmacologic interventions to control uterine contractility and prevent premature labor. The study investigates the effects of various drugs, including indomethacin and fenoprofen, on uterine activity in both human and monkey models.

A Promising Solution: Indomethacin and Fenoprofen for Premature Labor

This study reveals that indomethacin and fenoprofen effectively reduce uterine contractility without significant maternal or fetal side effects. The findings suggest that these drugs hold promise as clinically effective agents for managing premature labor, offering a valuable tool for healthcare providers in preventing premature births.

A Journey Through Pregnancy: Navigating the Sands of Premature Labor

This research underscores the importance of careful management of premature labor. By understanding the underlying mechanisms of uterine contractility and exploring effective pharmacologic interventions, healthcare providers can improve the outcomes for both mothers and babies.

Dr.Camel's Conclusion

This study offers valuable insights into the potential of pharmacologic interventions in managing premature labor. The findings suggest that indomethacin and fenoprofen could play a vital role in preventing premature births, contributing to safer and healthier pregnancies.
Date :
  1. Date Completed 1975-12-11
  2. Date Revised 2019-06-15
Further Info :

Pubmed ID

241259

DOI: Digital Object Identifier

10.1016/s0002-9378(16)33437-8

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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