Tolerance and biological activity of pentosan polysulfate after intramuscular or subcutaneous administration for ten days in human volunteers.

Author: AlbaredeJ L, BoneuB, BoulouxC, ChigotC, CorrellS, LansenJ, RobertM, SiéP, ThouvenotJ P

Paper Details 
Original Abstract of the Article :
This study reports on the tolerance and the pharmacological activity of pentosan polysulfate (PPS) administered to healthy volunteers for 10 days. Three groups of 10 subjects received either one daily injections of 100 mg of PPS by I. M. route (group I), or two daily injection of 50 mg of PPS by I. ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/2422778

データ提供:米国国立医学図書館(NLM)

Pentosan Polysulfate: Tolerance and Pharmacological Activity in Humans

This research, published in [Journal Name], explores the safety and effectiveness of pentosan polysulfate (PPS) when administered to healthy volunteers. This study involved three groups of volunteers who received different doses and routes of PPS administration for ten days. The study measured the tolerance and pharmacological activity of PPS, providing insights into its potential therapeutic applications.

Safety and Efficacy of Pentosan Polysulfate

The results of this study show that PPS is generally well-tolerated, with most side effects being mild and manageable. The researchers noted potential effects on liver enzymes and platelet counts, which require further investigation. They found that PPS exhibited a pharmacological activity that could potentially be beneficial for certain medical conditions.

Implications for Potential Therapies

The findings from this study provide valuable information about the safety and efficacy of PPS. This knowledge can inform the development of potential therapies for conditions that may benefit from PPS's pharmacological properties. Further research is needed to explore the potential benefits and risks of PPS in a wider range of patients and settings.

Dr.Camel's Conclusion

Think of PPS like a desert oasis - it's a potential source of relief and healing, but careful observation and assessment are necessary to ensure its safe and effective use. This research helps us understand the properties of PPS, allowing us to explore its potential benefits while remaining aware of its potential side effects.

Date :
  1. Date Completed 1986-05-30
  2. Date Revised 2006-11-15
Further Info :

Pubmed ID

2422778

DOI: Digital Object Identifier

2422778

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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