Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): a companion analysis of a randomised controlled trial.

Author: Badovinac-CrnjevicTanja, ChalchalHaji, ChapmanJudith-Anne W, CheungAngela M, ElliottCatherine R, GossPaul E, HershmanDawn L, IngleJames N, KhoslaSundeep, LindenHannah M, MussHyman B, PritchardKathleen I, RowlandKendrith, ScherJudite, ShepherdLois E, St LouisJessica, StearnsVered

Paper Details 
Original Abstract of the Article :
Treatment of breast cancer with aromatase inhibitors is associated with damage to bones. NCIC CTG MA.27 was an open-label, phase 3, randomised controlled trial in which women with breast cancer were assigned to one of two adjuvant oral aromatase inhibitors-exemestane or anastrozole. We postulated th...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/24636210

データ提供:米国国立医学図書館(NLM)

Aromatase Inhibitors: Navigating the Desert of Bone Health

Breast cancer treatment often involves aromatase inhibitors, medications that block the production of estrogen. These medications, while effective in fighting cancer, can also have unintended consequences for bone health. This research, like a desert explorer seeking a path through a treacherous landscape, investigates the impact of two aromatase inhibitors, exemestane and anastrozole, on bone mineral density (BMD).

Exemestane: A Potential Oasis for Bone Health

The study, like a desert oasis offering a respite from the harsh environment, suggests that exemestane, a mildly androgenic steroid, may have a less detrimental effect on bone health compared to anastrozole. This finding, much like a discovery of a hidden spring, provides a potential solution for minimizing the bone loss associated with aromatase inhibitor therapy.

Protecting Bone Health During Breast Cancer Treatment

The study's findings underscore the importance of monitoring bone health during breast cancer treatment with aromatase inhibitors. The study's results, like a map guiding a traveler through a vast desert, highlight the potential benefits of exemestane for preserving bone health.

Dr.Camel's Conclusion

This research is a testament to the ongoing quest for better breast cancer treatments that minimize side effects. The study's findings provide valuable insights into the potential of exemestane to protect bone health during aromatase inhibitor therapy. Just as a desert traveler seeks a path that minimizes the risk of dehydration, we must continue to explore new avenues for breast cancer treatment that safeguard the well-being of patients.

Date :
  1. Date Completed 2014-07-03
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24636210

DOI: Digital Object Identifier

NIHMS664000

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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