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Long-term open evaluation of amlodipine versus hydrochlorothiazide in patients with essential hypertension.

Author: RofmanB A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Amlodipine was as effective as hydrochlorothiazide in lowering blood pressure in 139 patients with hypertension. Amlodipine was associated with a higher incidence of side effects, but both drugs were well-tolerated.
Paper Details　
Original Abstract of the Article :
Amlodipine, a long-acting calcium antagonist, was compared with hydrochlorothiazide (HCTZ) in a long-term study of 139 patients. After a 2-week placebo run-in period, patients were randomly allocated to receive either amlodipine or HCTZ in a 2:1 patient ratio. After study week 12, those patients who...See full text at original site
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引用元：
https://doi.org/10.1097/00005344-198812007-00021

データ提供：米国国立医学図書館（NLM）

Amlodipine vs. Hydrochlorothiazide: A Long-Term Evaluation of Antihypertensive Therapies

Hypertension, or high blood pressure, is a major public health concern, affecting millions of people worldwide. This study, published in the Journal of Human Hypertension, compares the long-term efficacy and safety of two commonly prescribed antihypertensive medications, amlodipine and hydrochlorothiazide (HCTZ). The research team conducted a long-term study involving 139 patients with essential hypertension.

Comparing Antihypertensive Medications: Amlodipine vs. HCTZ

The study found that both amlodipine and HCTZ effectively lowered blood pressure in patients with essential hypertension. However, the incidence of treatment-related side effects was higher in the amlodipine group. The authors also noted that a significant number of patients required additional medication, atenolol, to achieve adequate blood pressure control. This highlights the need for individualized treatment approaches based on patient characteristics and response to therapy.

The Importance of Individualized Treatment

The study emphasizes the importance of personalized medicine in the management of hypertension. It demonstrates that there is no one-size-fits-all approach to treating high blood pressure. Clinicians need to carefully consider patient-specific factors, including age, co-morbidities, and individual responses to medications, to tailor treatment plans accordingly. This approach helps to optimize treatment efficacy and minimize side effects.

Dr. Camel's Conclusion

The desert is a harsh environment, with unpredictable weather patterns and limited resources. Like a camel adapting to the desert's challenges, patients with hypertension require a tailored approach to manage their condition. This study provides valuable insights into the efficacy and safety of different antihypertensive medications, reminding us that the best treatment for one patient may not be the best treatment for another.

Date :
  1. Date Completed 1989-05-11
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

2467139

DOI: Digital Object Identifier

10.1097/00005344-198812007-00021

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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