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The influence of nifedipine and diltiazem on serum theophylline concentration-time profiles.

Author: HaffnerC A, KendallM J, SmithS R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nifedipine and diltiazem have a small effect on theophylline levels in the blood. Theophylline levels may be slightly higher during nifedipine therapy, but the difference is not significant. However, this may be clinically relevant as high theophylline levels can cause side effects.
Paper Details　
Original Abstract of the Article :
Chronic dosing studies in normal volunteers have shown that both nifedipine and diltiazem exert a small effect on serum theophylline concentrations, which tend to be higher during concurrent nifedipine therapy. The differences were not significant but may be of clinical interest as theophylline caus...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2710.1989.tb00263.x

データ提供：米国国立医学図書館（NLM）

Theophylline and Calcium Channel Blockers: A Complex Interaction

The use of theophylline, a bronchodilator, and calcium channel blockers, commonly used for cardiovascular conditions, is a common scenario in clinical practice. This study investigated the potential interaction between theophylline and two calcium channel blockers, nifedipine and diltiazem, to understand how these medications might affect each other's levels in the body.

Navigating the Sands: Potential Interactions

The researchers found that both nifedipine and diltiazem can have a small effect on theophylline levels, with nifedipine tending to increase theophylline levels slightly. While the differences were not statistically significant, they highlight the need to be aware of potential drug interactions and monitor patients closely when these medications are used together.

A Balancing Act: Dose Adjustments and Monitoring

This study emphasizes the importance of careful monitoring and potential dose adjustments when theophylline and calcium channel blockers are used concurrently. Healthcare providers should be vigilant in monitoring theophylline levels to ensure optimal therapeutic efficacy and minimize the risk of adverse effects.

Dr. Camel's Conclusion

The researchers have shed light on the complex interaction between theophylline and calcium channel blockers, revealing a subtle but potentially significant interplay. By being mindful of these potential interactions, we can better navigate the desert of drug therapy and ensure the well-being of our patients.

Date :
  1. Date Completed 1990-01-05
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

2584285

DOI: Digital Object Identifier

10.1111/j.1365-2710.1989.tb00263.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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