Paper Details

  1. Home
  2. Paper Details

Prior treatment with diuretic augments the hypokalemic and electrocardiographic effects of inhaled albuterol.

Author: LipworthB J, McDevittD G, StruthersA D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

High doses of inhaled albuterol, a bronchodilator, can cause hypokalemia and hypomagnesemia, which may be exacerbated by diuretic therapy, potentially leading to cardiac arrhythmias.
Paper Details　
Original Abstract of the Article :
High doses of inhaled albuterol produce substantial improvements in bronchodilatation but are associated with dose-related systemic side effects including hypokalemia and hypomagnesemia. Concomitant diuretic therapy also produces these metabolic sequelae and may therefore precipitate cardiac arrhyth...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0002-9343(89)90438-5

データ提供：米国国立医学図書館（NLM）

Albuterol and Diuretics: A Cautionary Tale in the Desert of Drug Interactions

Inhaled albuterol is a commonly used medication for asthma, providing relief from the constricted airways that can make breathing feel like a struggle through a desert sandstorm. This study explores the potential for drug interactions between albuterol and diuretics, medications that help remove excess fluid from the body. It's like navigating a desert landscape, where the combination of certain elements can create unexpected and potentially dangerous conditions.

Potentiation of Effects: A Cautionary Reminder

The study's findings highlight the potential for a dangerous interaction between high-dose inhaled albuterol and diuretics. The researchers observed that prior treatment with a diuretic augmented the hypokalemic and electrocardiographic effects of albuterol, increasing the risk of cardiac arrhythmias. This is like a traveler in the desert who has already lost a significant amount of water and is then exposed to extreme heat, putting them at greater risk of dehydration and exhaustion.

Navigating the Desert of Drug Interactions: Informed Decision-Making is Key

For those taking both albuterol and diuretics, this study underscores the importance of careful monitoring and close collaboration with a healthcare professional. It's crucial to discuss any potential risks and to adjust dosages as needed to ensure safe and effective treatment. By staying informed and proactively managing medication use, we can navigate the desert of drug interactions with greater caution and protect our health.

Dr.Camel's Conclusion

This research emphasizes the importance of understanding potential drug interactions, especially when combining medications with the potential to affect electrolyte balance. It's a reminder that the desert of pharmaceuticals is filled with interconnected pathways and potential dangers. By carefully considering these factors and working closely with our healthcare providers, we can minimize the risk of unintended consequences and navigate the desert of medication use with greater confidence and safety.

Date :
  1. Date Completed 1989-07-06
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

2729315

DOI: Digital Object Identifier

10.1016/0002-9343(89)90438-5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.