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Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial.
Author: AndersenSusan L, BoerFrits, BottelierMarco A, BouzianeCheima, BronEsther E, GeurtsHilde M, GrooteInge R, KleinStefan, LindauerRamon J L, LucassenPaul J, MutsaertsHenk-Jan M M, NiessenWiro J, OpmeerBrent C, RenemanLiesbeth, RomboutsSerge A R B, SchranteeAnouk, TammingaHyke G H, ZwindermanAeilko H
Original Abstract of the Article :
IMPORTANCE: Although numerous children receive methylphenidate hydrochloride for the treatment of attention-deficit/hyperactivity disorder (ADHD), little is known about age-dependent and possibly lasting effects of methylphenidate on the human dopaminergic system. OBJECTIVES: To determine whether t...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/27487479
データ提供:米国国立医学図書館(NLM)
Methylphenidate and the Brain: A Tale of Two Ages
Methylphenidate is a medication commonly used to treat [attention-deficit/hyperactivity disorder (ADHD)] which is like a mischievous camel that has trouble focusing on the long journey across the desert. This study investigates the effects of methylphenidate on the [dopaminergic system] in the brain, particularly looking at the differences between [young] and [adult] patients with ADHD. It's like exploring how a camel's brain adapts to the desert environment based on its age and experience.
The research involved a [randomized clinical trial], where participants were randomly assigned to receive either methylphenidate or a placebo. This is like organizing a camel caravan, ensuring each camel has a fair chance of receiving the best treatment. The researchers found that methylphenidate had a significant impact on the [dopaminergic system] of younger patients but not adults. This is like observing how a young camel adapts to the harsh desert conditions more readily than an older camel who has already developed coping mechanisms.
Age Matters: Methylphenidate's Impact on the Brain
This study reveals that methylphenidate's impact on the brain varies significantly based on age. It's like discovering that the desert affects a young camel differently than an older one. The findings underscore the importance of considering individual factors, such as age, when prescribing medications.
Navigating ADHD: A Personalized Approach
This research highlights the complex interplay between age, medication, and brain function. It's like recognizing the unique challenges and adaptations of each camel as it traverses the desert. The findings emphasize the need for a personalized approach to treating ADHD, taking into account individual characteristics and needs.
Dr. Camel's Conclusion
This study highlights the age-dependent effects of methylphenidate on the brain's dopaminergic system. It's like recognizing the unique challenges and adaptations of a camel as it traverses the desert. The findings underscore the importance of a personalized approach to treating ADHD, considering individual factors, such as age.
Date :
- Date Completed 2017-05-08
- Date Revised 2018-11-13
Further Info :
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