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Immunoenhancement with combined rabies and aluminium-adjuvanted tetanus vaccines.

Author: KhaoplodP, PhanpanichT, PhanuphakP, RoumiantzeffM, SriwanthanaB, WonguraiS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Combining tetanus toxoid with purified Vero cell rabies vaccine (PVRV) in the 2-1-1 regimen significantly increased anti-rabies antibody levels, but only when aluminum hydroxide-adsorbed tetanus toxoid was used. This combination did not affect anti-tetanus antibody levels or increase side effects.
Paper Details　
Original Abstract of the Article :
The effect of combining tetanus toxoid in the same syringe with purified Vero cell rabies vaccine (PVRV) was investigated in the 2-1-1 regimen of PVRV. The 2-1-1 regimen alone was as immunogenic as the five-dose regimen, while saving one dose of vaccine and two clinic visits. When aluminium hydroxid...See full text at original site
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引用元：
https://doi.org/10.1016/0264-410x(89)90238-7

データ提供：米国国立医学図書館（NLM）

Harnessing the Power of Aluminum Adjuvant: A New Approach to Rabies Vaccination

This research ventures into the fascinating world of vaccine development, exploring the potential of combining rabies and tetanus vaccines for a more efficient and effective immunization strategy. The study investigates the efficacy of combining tetanus toxoid with purified Vero cell rabies vaccine (PVRV) in a simplified 2-1-1 regimen, reducing the number of vaccine doses and clinic visits.

Boosting Immunity: The Role of Aluminum Adjuvant

The study found that the addition of aluminum hydroxide-adsorbed tetanus toxoid significantly increased anti-rabies antibody levels, highlighting the importance of aluminum adjuvant in boosting immune responses. This discovery provides a valuable tool for optimizing rabies vaccination strategies, offering a more effective and efficient approach to protecting individuals from this deadly disease.

Improving Vaccination: A Step Towards a Healthier Future

By leveraging the power of aluminum adjuvant and combining rabies and tetanus vaccines, we can potentially improve vaccination strategies, making them more effective, efficient, and accessible. This research paves the way for developing a more streamlined and potent immunization approach, ensuring a healthier future for all.

Dr. Camel's Conclusion

This study unveils the power of aluminum adjuvant in enhancing rabies vaccination. By cleverly combining rabies and tetanus vaccines and harnessing the adjuvant effect, we can create a more effective and convenient immunization strategy. This research offers a refreshing oasis in the desert of vaccine development, bringing us closer to a future where we can effectively combat this deadly disease.

Date :
  1. Date Completed 1989-10-16
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

2781858

DOI: Digital Object Identifier

10.1016/0264-410x(89)90238-7

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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