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Acebutolol in essential hypertension: results of two multicenter studies against placebo and propranolol.

Author: DavidovM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Acebutolol effectively reduced blood pressure in patients with essential hypertension, achieving a therapeutic goal in a significantly higher percentage of patients compared to placebo. Acebutolol was better tolerated than propranolol, with fewer central nervous system side effects and a lesser effect on heart rate.
Paper Details　
Original Abstract of the Article :
Two double-blind multicenter studies compared acebutolol with placebo (acebutolol, N = 121; placebo, N = 116) and with propranolol (acebutolol, N = 186; propranolol, N = 190) in essential hypertension. Acebutolol significantly reduced mean sitting diastolic blood pressure from 99.2 +/- 0.3 mm Hg at ...See full text at original site
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引用元：
https://doi.org/10.1016/0002-8703(85)90702-1

データ提供：米国国立医学図書館（NLM）

Acebutolol: A Safe and Effective Treatment for Hypertension

The field of hypertension management is continuously seeking to improve treatment options. This research investigates the efficacy and safety of acebutolol, a beta-blocker, in patients with essential hypertension. The researchers conducted two double-blind, multicenter studies, comparing acebutolol to placebo and propranolol. Their findings provide valuable insights into the comparative benefits of acebutolol in managing hypertension, highlighting its effectiveness and favorable side effect profile.

A Balanced Approach: Acebutolol's Effectiveness in Hypertension

The study demonstrates that acebutolol effectively reduces blood pressure in patients with essential hypertension, comparable to propranolol. The researchers also found that acebutolol was better tolerated than propranolol, with fewer central nervous system side effects and a less pronounced effect on heart rate. The findings provide reassurance regarding the effectiveness and safety of acebutolol as a treatment option for hypertension.

A Safe Oasis in the Desert of Hypertension

The research underscores the safety and effectiveness of acebutolol in managing hypertension. The findings provide valuable insights for healthcare providers in choosing the most appropriate medication for individual patients, considering potential side effects and patient preferences. The study encourages further exploration of acebutolol as a treatment option for hypertension, recognizing its favorable side effect profile and effectiveness.

Dr.Camel's Conclusion

This research offers a comprehensive evaluation of acebutolol, a beta-blocker used to manage hypertension. The findings are like a refreshing oasis in the desert of hypertension, providing reassurance about the drug's effectiveness and safety. The study encourages a balanced approach, considering individual patient needs and preferences when selecting the appropriate medication.

Date :
  1. Date Completed 1985-06-20
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

2859780

DOI: Digital Object Identifier

10.1016/0002-8703(85)90702-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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