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Efficacy and safety of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg in the treatment of acute low back pain: a phase III, randomized, double blind, controlled trial.

Author: AlbamonteEmilio, CaggianoGiuseppe, CostantinoCosimo, GiossiAttilio, MancusoMaurizio, RigamontiAlberto, SprovieroEgidio, TornariPaolo

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The study found that a 5-day treatment with IM diclofenac+thiocolchicoside FDC in a 4-mL volume was as effective and well tolerated as the separate injection of the two components in improving pain symptoms in patients with acute moderate-severe LBP.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The management of acute low back pain (LBP) is directed to obtain early and maximum relief of the local and regional pain, and to improve mobility and physical function. AIM: To evaluate the effects of a 4 mL-volume diclofenac 75mg/thiocolchicoside 4mg fixed dose combination (FDC) for i...See full text at original site
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引用元：
https://doi.org/10.23736/S1973-9087.17.04923-1

データ提供：米国国立医学図書館（NLM）

Diclofenac + Thiocolchicoside for Acute Low Back Pain

Navigating the desert of chronic pain can be a long and arduous journey. This research delves into the effectiveness of a combination medication, diclofenac + thiocolchicoside, in treating acute low back pain (LBP). This study aims to explore whether this combination offers a quicker and more effective way to cross the desert of pain and regain mobility.

The researchers compared the effects of this combination medication with separate injections of the two components. They carefully examined its effectiveness and safety in a randomized, controlled, double-blind trial involving a diverse group of adult outpatients experiencing moderate to severe LBP. They wanted to know if this combination was like a trusty camel, guiding them safely through the pain, or if it was like a mirage, offering false hope.

Their findings suggest that the combination medication was as effective and well-tolerated as separate injections, offering a potential improvement in treatment convenience for patients.

Easing the Desert of Back Pain with Diclofenac + Thiocolchicoside

This research provides valuable evidence for the efficacy and safety of a fixed combination of diclofenac + thiocolchicoside in treating acute LBP. The study found that this combination was as effective as separate injections, suggesting that it might be a convenient and well-tolerated option for patients. It’s like finding a combination of oasis in the desert, offering a faster and easier way to reach relief.

Finding the Right Path to Pain Relief

This research emphasizes the importance of finding the right medication to effectively manage pain. It's like choosing the right path through a desert, one that offers the most efficient and comfortable journey.

Dr.Camel's Conclusion

This study suggests that the combination of diclofenac + thiocolchicoside offers a promising solution for treating acute LBP. It’s like finding a shortcut through the desert of pain, allowing patients to reach relief more quickly and conveniently.

Date :
  1. Date Completed 2018-10-31
  2. Date Revised 2018-10-31
Further Info :

Pubmed ID

29265793

DOI: Digital Object Identifier

10.23736/S1973-9087.17.04923-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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