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Once daily amlodipine in the treatment of mild to moderate hypertension.

Author: JeffersT A, PetrieJ C, RobbO J, ScottA K, TowlerH M, WebsterJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Amlodipine, a calcium channel blocker, demonstrated significant blood pressure reduction in patients with mild to moderate hypertension compared to placebo. The average reduction was 16/12 mmHg supine and 14/4 mmHg standing. The effect was reversible with the discontinuation of amlodipine, and the drug was generally well-tolerated, with only a few patients experiencing minor ankle edema.
Paper Details　
Original Abstract of the Article :
1. The antihypertensive efficacy of once-daily amlodipine was studied in a group of 30 patients with mild to moderate hypertension in a double-blind, placebo controlled parallel group study. The dose range of amlodipine was 2.5-10 mg daily titrated at 2 weekly intervals for a total treatment period ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2125.1987.tb03236.x

データ提供：米国国立医学図書館（NLM）

Once-Daily Amlodipine for Mild to Moderate Hypertension

This research explores the effectiveness of amlodipine, a calcium channel blocker, in treating patients with mild to moderate hypertension, a condition characterized by high blood pressure. The study investigates the antihypertensive effects of once-daily amlodipine in a double-blind, placebo-controlled trial. Researchers aimed to determine the optimal dose and efficacy of amlodipine in lowering blood pressure.

Amlodipine's Potential for Blood Pressure Control

The study's findings suggest that once-daily amlodipine is effective in reducing blood pressure in patients with mild to moderate hypertension. This discovery is like finding a refreshing oasis in the desert of high blood pressure, offering a way to quench the thirst for healthy blood pressure levels.

Navigating the Complexities of Hypertension Management

This research underscores the importance of carefully considering the individual needs and characteristics of each patient when prescribing antihypertensive medications. Just as a camel caravan needs to adapt its route based on the unique terrain, so too must healthcare providers personalize treatment plans for those with hypertension.

Dr. Camel's Conclusion

This research provides valuable insights into the effectiveness of amlodipine in treating mild to moderate hypertension. It emphasizes the need for individualized treatment plans and careful monitoring to ensure optimal blood pressure control. Just as a camel caravan needs to maintain a steady pace to reach its destination, so too must we work diligently to manage our blood pressure and maintain good cardiovascular health.
Date :
  1. Date Completed 1988-04-14
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2964253

DOI: Digital Object Identifier

10.1111/j.1365-2125.1987.tb03236.x

SNS
PICO Info
in preparation
Languages

English

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