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Effects of Ticagrelor, Prasugrel, or Clopidogrel on Endothelial Function and Other Vascular Biomarkers: A Randomized Crossover Study.

Author: , AkkerhuisK Martijn, AriottiSara, BrugalettaSalvatore, GianniUmberto, JanssensGladys, KaragiannisAlexios, LeonardiSergio, Ortega-PazLuis, RimoldiStefano F, ValgimigliMarco, WindeckerStephan, van LeeuwenMaarten, van den BergeJan C

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ticagrelor did not improve endothelial function or increase systemic adenosine plasma levels in stabilized patients who suffered from an acute coronary syndrome, compared to prasugrel and clopidogrel.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The study sought to assess whether treatment with ticagrelor, as compared with prasugrel and clopidogrel, improves endothelium-dependent dilation throughout the course of the treatment and other vascular biomarkers, including systemic adenosine plasma levels. BACKGROUND: The in vivo off...See full text at original site
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引用元：
https://doi.org/10.1016/j.jcin.2018.04.022

データ提供：米国国立医学図書館（NLM）

The Effects of Different Antiplatelet Drugs on Vascular Function

This study delves into the intricate world of antiplatelet drugs, exploring their impact on vascular function. The researchers conducted a randomized crossover study to compare the effects of ticagrelor, prasugrel, and clopidogrel, three commonly used antiplatelet medications, on endothelial function and other vascular biomarkers. They focused on stable patients who had previously experienced acute coronary syndrome (ACS), a condition involving a sudden blockage or rupture of blood vessels.

The study revealed a surprising finding: ticagrelor did not demonstrate significant improvement in endothelial function compared to prasugrel or clopidogrel, despite its known off-target effects. This suggests that ticagrelor may not be the most advantageous choice for patients seeking to improve vascular health. Imagine a camel caravan exploring a desert with multiple oases - the caravan needs to carefully select the oasis that offers the best resources for its journey. Similarly, patients need to carefully consider their treatment options based on their individual needs and goals.

Navigating the Vascular Terrain

The study highlights the complexity of antiplatelet drug effects on vascular function. It reminds us that the choice of medication should be tailored to individual patient needs and goals, considering both the intended effect on platelet aggregation and potential off-target effects. Just like a camel caravan navigating a challenging desert, we must carefully select the optimal path to reach our destination.

Dr.Camel's Conclusion

Antiplatelet drugs play a crucial role in managing cardiovascular health. This study provides insights into the specific effects of ticagrelor, prasugrel, and clopidogrel on vascular function. It underscores the importance of tailoring treatment choices to individual patient needs and goals, considering the diverse range of potential effects. Just like a camel caravan navigating a vast desert, we need to make informed decisions to ensure a successful journey towards cardiovascular well-being.

Date :
  1. Date Completed 2019-11-20
  2. Date Revised 2019-11-20
Further Info :

Pubmed ID

29805112

DOI: Digital Object Identifier

10.1016/j.jcin.2018.04.022

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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