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Clinical Overview and Considerations for the Management of Opioid-induced Constipation in Patients With Chronic Noncancer Pain.

Author: ViscusiEugene R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Prescription medications for opioid-induced constipation (OIC) include peripherally acting µ-opioid receptor antagonists (PAMORA) and chloride channel activators. These medications are effective for improving OIC in patients with chronic noncancer pain, but potential gastrointestinal side effects need to be considered.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Opioid analgesics may be associated with chronic adverse effects, such as opioid-induced constipation (OIC). Available and emerging prescription medications for OIC in patients with chronic noncancer pain are described, including concerns and challenges associated with OIC management. M...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343957/

データ提供：米国国立医学図書館（NLM）

Managing Opioid-Induced Constipation: A Comprehensive Overview

Opioid analgesics are often used to manage chronic pain. While effective in relieving pain, opioids can lead to a common side effect known as opioid-induced constipation (OIC). This review article, published in the American Journal of Gastroenterology, provides a comprehensive overview of OIC, discussing its characteristics, available treatment options, and challenges associated with its management. Navigating this condition is like trying to find your way through a dense desert with limited resources – understanding the terrain and available tools is crucial for successful navigation.

Understanding Opioid-Induced Constipation: A Common Challenge

OIC is characterized by changes in bowel habits, including reduced frequency, straining, and a feeling of incomplete evacuation. The review highlights the efficacy of prescription medications like PAMORAs (peripherally acting µ-opioid receptor antagonists) and lubiprostone in treating OIC. The article emphasizes the importance of comprehensive patient care, including addressing constipation-related symptoms to optimize pain management and improve patient quality of life.

Lifestyle Adjustments and Preventive Measures for OIC

While medications can play a vital role in managing OIC, lifestyle adjustments can also be beneficial. Increasing fiber and fluid intake, engaging in regular exercise, and considering over-the-counter laxatives or stool softeners can help alleviate constipation symptoms. Remember, even in the harshest desert conditions, a little ingenuity and effort can make a big difference.

Dr. Camel's Conclusion

Managing OIC effectively is essential for ensuring the overall well-being of patients taking opioids for chronic pain. This review provides valuable insights into the complexities of OIC, highlighting the importance of a multi-faceted approach involving medication, lifestyle changes, and close patient monitoring.

Date :
  1. Date Completed 2020-03-31
  2. Date Revised 2023-10-05
Further Info :

Pubmed ID

30289777

DOI: Digital Object Identifier

PMC6343957

SNS
PICO Info
in preparation
Languages

English

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