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Simplification of combination antiretroviral therapy (cART) and the brain-a real-life experience.

Author: ArendtGabriele, OrhanEser, SchloniesSvenja, StüveOlaf

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Simplified antiretroviral therapy (cART) regimens, with fewer drugs, are increasingly used to treat HIV infection. This study analyzed a cohort of 4992 HIV-positive patients to investigate the impact of simplified therapy on neurocognitive performance. The study found that while simplified regimens improved immunological and virological outcomes, they did not always improve neurocognitive function. Some patients, especially those who were not well-controlled virologically before the switch, showed a decline in neurocognitive performance.
Paper Details　
Original Abstract of the Article :
Modern antiretroviral combination therapy (cART) has transformed HIV from a life-threatening infection into a chronic disease. However, the life-long treatment has side effects that frequently have a negative impact on patients' quality of life. Thus, there are some efforts to "simplify" therapy, i....See full text at original site
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引用元：
https://doi.org/10.1007/s13365-018-0701-x

データ提供：米国国立医学図書館（NLM）

Simplified Antiretroviral Therapy: A Camel's Perspective on Brain Health in HIV

The world of HIV/AIDS is a complex and evolving desert, where advances in treatment have brought hope and progress. This research explores the impact of simplified antiretroviral therapy (cART) regimens on brain health in HIV-positive individuals. The authors investigated whether simplifying cART regimens, by reducing the number of antiretroviral medications, could affect neurocognitive performance in a large cohort of patients.

A Navigational Challenge: Simplifying cART Regimens

Imagine a camel traversing a desert, navigating a complex network of paths and trails. In a similar way, simplifying cART regimens can present a navigational challenge. This research examined the effects of switching to simplified cART regimens on brain health in HIV-positive individuals. The authors found that while simplified regimens can improve systemic infection markers, they may not always lead to improvements in neurocognitive function.

The Camel's Advice: Prioritizing Brain Health

As a camel, I understand the importance of staying alert and attentive to navigate challenging terrains. This research underscores the need to carefully consider the potential impact of cART regimens on brain health in HIV-positive individuals. While simplified regimens can be beneficial for overall health, it's essential to monitor for any changes in cognitive function and work with healthcare providers to optimize treatment plans.

Dr.Camel's Conclusion

This research provides valuable information about the potential impact of cART simplification on brain health in HIV-positive individuals. By understanding the nuances of cART regimens and their effects on the brain, clinicians can provide more comprehensive and personalized care. Like a camel who has learned to adapt to the ever-changing landscape of the desert, researchers are continuously seeking new knowledge and approaches to improve the lives of individuals living with HIV/AIDS.

Date :
  1. Date Completed 2020-09-11
  2. Date Revised 2020-09-11
Further Info :

Pubmed ID

30628025

DOI: Digital Object Identifier

10.1007/s13365-018-0701-x

SNS
PICO Info
in preparation
Languages

English

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