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Comparative effects of acebutolol and labetalol on peripheral hemodynamics in healthy volunteers.

Author: Duchene-MarullazP, KantelipJ P, WurmM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Acebutolol reduced heart rate at rest and after exercise, while labetalol reduced heart rate only after exercise. Labetalol increased blood flow in the calf and first toe, while acebutolol tended to lower resistance in the calf but increase resistance in the first toe.
Paper Details　
Original Abstract of the Article :
1. During a 28-day treatment period, 10 healthy volunteers in a cross-over, double-blind study received at random 200 mg of either acebutolol or labetalol twice a day. Each treatment period was followed by administration of a placebo over an equal length of time. 2. Only acebutolol reduced heart rat...See full text at original site
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引用元：
https://doi.org/10.1111/j.1472-8206.1988.tb01006.x

データ提供：米国国立医学図書館（NLM）

Acebutolol vs. Labetalol: A Comparative Analysis of Peripheral Hemodynamics

[Peripheral hemodynamics] plays a crucial role in regulating blood flow throughout the body, like a complex irrigation system in a vast desert. This study compares the effects of two beta-blockers, [acebutolol] and [labetalol], on [peripheral hemodynamics] in healthy volunteers. This is like comparing two different approaches to managing water flow through a desert landscape, each with unique advantages and disadvantages.

Labetalol: Enhancing Peripheral Blood Flow

The study found that [labetalol] increased [blood flow] in the [calf] and [first toe], while [acebutolol] tended to increase [blood flow] in the [calf] but decreased it in the [first toe]. This is like finding a system that improves water distribution, ensuring adequate hydration across the desert ecosystem. The researchers suggest that [labetalol] might be more effective in improving [peripheral circulation] than [acebutolol].

Beta-Blockers and Peripheral Hemodynamics: A Balancing Act

This study highlights the importance of understanding the individual effects of [beta-blockers] on different aspects of [peripheral hemodynamics]. This is like navigating a desert landscape with a variety of terrain, adapting our approach based on the specific challenges we encounter. Further research is needed to determine the optimal [beta-blocker] for specific clinical conditions and to minimize potential side effects on [peripheral circulation].

Dr. Camel's Conclusion

This study provides valuable insights into the differences in [peripheral hemodynamic] effects between two commonly used [beta-blockers]. The findings suggest that [labetalol] might be more beneficial for improving [peripheral blood flow] than [acebutolol], although further research is needed to confirm this finding and to explore the long-term effects of these medications. This is like discovering new and efficient irrigation systems that optimize water distribution and enhance the overall health of the desert ecosystem.
Date :
  1. Date Completed 1989-04-27
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

3069682

DOI: Digital Object Identifier

10.1111/j.1472-8206.1988.tb01006.x

SNS
PICO Info
in preparation
Languages

English

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