Paper Details

  1. Home
  2. Paper Details

Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis: A randomized controlled clinical trial.

Author: ChenXiu-Min, HuangQing-Chun, HuangRun-Yue, LiZhan-Guo, LiuLiang, PanHu-Dan, QiuPing, WuJia-Qi, XiaoYao, XieZhi-Xin, ZhouHua, ZhouYing-Yan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Combining different conventional medications to treat rheumatoid arthritis (RA) is often effective but can have significant side effects. This study emphasizes the need for a safer and more effective alternative to expensive biological treatments, focusing on methotrexate (MTX) combination therapy. The aim is to find a combination of medications that provides a high level of effectiveness with fewer side effects.
Paper Details　
Original Abstract of the Article :
A combination of conventional disease-modifying anti-rheumatic drugs improves the treatment of rheumatoid arthritis but with high side-effects. Methotrexate (MTX) combination therapy that with high therapeutic efficacy and low toxicity is in demand in many countries to replace the use of expensive b...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.phymed.2018.12.030

データ提供：米国国立医学図書館（NLM）

Combination Therapy for Rheumatoid Arthritis: Exploring New Avenues

This study investigates the effectiveness of [combination therapy] for [rheumatoid arthritis], a chronic inflammatory disease. The researchers conducted a [randomized controlled trial] to compare the outcomes of [methotrexate] combined with either [sinomenine] or [leflunomide] in treating [active rheumatoid arthritis]. The findings, much like a desert explorer discovering a new route, suggest that [combination therapy] with [methotrexate] may offer a promising approach to managing [rheumatoid arthritis] with high therapeutic efficacy and low toxicity. The study highlights the potential of [combination therapy] to provide a more effective and well-tolerated alternative to [expensive biological agents] for [rheumatoid arthritis] treatment.

Rheumatoid Arthritis Treatment: A Journey of Hope

The study's findings offer a glimmer of hope for individuals living with [rheumatoid arthritis]. It's like finding a hidden oasis in the desert of chronic pain and inflammation. The research suggests that [combination therapy] with [methotrexate] may offer a new avenue for effective treatment, potentially improving quality of life and reducing the burden of disease. This encourages continued exploration of [combination therapy] and other innovative approaches to managing [rheumatoid arthritis].

Living with Rheumatoid Arthritis: Embracing a Holistic Approach

Managing [rheumatoid arthritis] can be a lifelong journey, like navigating a vast desert with its unpredictable challenges. The study underscores the importance of working with a healthcare professional to find the most effective treatment approach. This may involve exploring different [combination therapies], [lifestyle modifications], and other strategies to manage [rheumatoid arthritis] symptoms and maintain a good quality of life.

Dr. Camel's Conclusion

This research sheds light on the promising potential of [combination therapy] in treating [rheumatoid arthritis]. It's like discovering a new path through the desert, offering a more effective and well-tolerated route to improved health. The study encourages further research to explore the optimal [combination therapy] approaches for managing [rheumatoid arthritis] and improving outcomes for patients living with this chronic condition.

Date :
  1. Date Completed 2019-06-24
  2. Date Revised 2019-06-24
Further Info :

Pubmed ID

30851515

DOI: Digital Object Identifier

10.1016/j.phymed.2018.12.030

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.