Evaluation of Drinking Risk Levels as Outcomes in Alcohol Pharmacotherapy Trials: A Secondary Analysis of 3 Randomized Clinical Trials.

Author: , AntonRaymond F, FalkDaniel E, FertigJoanne, HasinDeborah S, JohnsonBankole, KranzlerHenry R, LittenRaye Z, MannKarl F, MeulienDidier, O'MalleyStephanie S, RyanMegan, SlaterMegan, WitkiewitzKatie

Paper Details 
Original Abstract of the Article :
The US Food and Drug Administration recognizes total abstinence and no heavy drinking days as outcomes for pivotal pharmacotherapy trials for alcohol use disorder (AUD). Many patients have difficulty achieving these outcomes, which can discourage seeking treatment and has slowed the development of m...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450273/

データ提供:米国国立医学図書館(NLM)

Redefining Success: Evaluating Drinking Risk Levels in Alcohol Pharmacotherapy Trials

The journey towards recovery from alcohol use disorder (AUD) is often marked by setbacks and relapses. This study, like a meticulous scholar examining historical records, delves into the complexities of measuring success in alcohol pharmacotherapy trials. The authors, with the keen observation of a seasoned desert traveler, challenge traditional outcome measures, highlighting the need for a more nuanced assessment of drinking risk levels.

The US Food and Drug Administration (FDA) currently recognizes total abstinence and no heavy drinking days as key outcomes for evaluating the effectiveness of medications for AUDs. However, this study, like a desert oasis offering alternative perspectives, argues that these measures may not fully capture the realities of recovery, often leading to unrealistic expectations and discouraging patients from seeking treatment.

A Broader Perspective: Beyond Abstinence and Heavy Drinking Days

This study proposes a shift in focus, urging researchers to consider a broader spectrum of drinking risk levels, including reduced consumption and fewer heavy drinking days, as meaningful outcomes in pharmacotherapy trials. This approach, like a desert bloom defying the harsh conditions, acknowledges the challenges of achieving complete abstinence and recognizes the value of incremental progress.

A More Compassionate Approach: Supporting Individual Goals and Recovery Journeys

This study, like a compassionate guide offering support during a challenging journey, calls for a more humane and patient-centered approach to evaluating alcohol pharmacotherapy. By acknowledging the complexities of AUDs and recognizing the value of individual progress, we can better support patients on their path to recovery.

Dr. Camel's Conclusion

Recovery from AUDs is a complex and individualized journey. This study challenges us to move beyond simplistic measures of success and adopt a more compassionate and nuanced approach to evaluating treatment outcomes. By embracing a broader perspective and acknowledging the value of individual progress, we can create a more supportive and effective system for those seeking help with AUDs.

Date :
  1. Date Completed 2020-02-14
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

30865232

DOI: Digital Object Identifier

PMC6450273

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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