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Pharmacology, toxicology and clinical safety of glycopyrrolate.

Author: AbelsChristoph, ChabicovskyMonika, KilicAna, MasurClarissa, SoeberdtMichael, WinklerSwantje

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This abstract discusses the safety and efficacy of glycopyrronium bromide, an anticholinergic drug used to treat various conditions, including chronic obstructive pulmonary disease, excessive salivation, peptic ulcers, and hyperhidrosis. It concludes that the benefits of glycopyrronium bromide generally outweigh the risks in chronic use indications.
Paper Details　
Original Abstract of the Article :
The clinical use of the anticholinergic glycopyrrolate dates back to the early 1960s when it was first approved in the U.S. Since then, oral and inhalation formulations have been developed as therapeutic agents inhibiting the muscarinic acetylcholine receptor in various indications including chronic...See full text at original site
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引用元：
https://doi.org/10.1016/j.taap.2019.03.016

データ提供：米国国立医学図書館（NLM）

Pharmacology, Toxicology, and Clinical Safety of Glycopyrrolate

This study focuses on the safety profile of glycopyrrolate, an anticholinergic agent with a rich history of use in various medical settings. The authors provide a comprehensive overview of glycopyrrolate's pharmacology, toxicology, and clinical safety, highlighting its potential benefits and risks.

Glycopyrrolate: A Versatile and Generally Safe Anticholinergic

The study reveals that glycopyrrolate, despite its long-standing use, remains a generally safe and effective therapeutic agent for treating conditions like chronic obstructive pulmonary disease (COPD), excessive salivation, peptic ulcers, and hyperhidrosis. Its favorable safety profile, particularly its limited CNS side effects and lack of phototoxicity, genotoxicity, and carcinogenicity, makes it suitable for chronic indications.

Glycopyrrolate: A Beacon of Safety in the Desert of Medications

The study's findings offer reassurance regarding the safety of glycopyrrolate in various clinical settings. It's like discovering a reliable oasis in the vast desert of medications, providing a safe and effective treatment option for a range of conditions.

Dr.Camel's Conclusion

This study provides valuable insights into the pharmacology, toxicology, and clinical safety of glycopyrrolate. It's a testament to the ongoing efforts to ensure the safe and effective use of medications, offering a reliable guide through the intricate landscape of pharmaceuticals.

Date :
  1. Date Completed 2020-04-13
  2. Date Revised 2020-04-13
Further Info :

Pubmed ID

30905688

DOI: Digital Object Identifier

10.1016/j.taap.2019.03.016

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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