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Amlodipine alters hemorheological parameters: Increased efficacy at the cost of edema?

Author: ArunkumarS, LokhandwalaYash, PadgaonkarK, PanickerGopi, PuniyaniR R, RavindraR P, SharmaRajeev, VadiveluRamalingam

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study reviewed the literature on the side effect of edema associated with calcium channel blockers, specifically focusing on amlodipine. While the hemodilutory property of amlodipine may contribute to its antihypertensive action, further research is needed to understand the mechanisms behind the persistent edema side effect.
Paper Details　
Original Abstract of the Article :
Despite several decades of use of calcium channel blockers, the side effect of edema persists as a class effect, and its mechanism is unresolved. Amlodipine has effects on hemorheology (HR), and its hemodilutory property may partly contribute to its antihypertensive action. This aspect is not well s...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477139/

データ提供：米国国立医学図書館（NLM）

Amlodipine and Hemorheology: Unveiling the Mystery of Edema

Calcium channel blockers are widely used to treat hypertension, but a persistent side effect, edema, remains a puzzle. This study investigates the role of hemorheology, the study of blood flow properties, in the development of edema associated with amlodipine. Amlodipine, a specific calcium channel blocker, is known to affect blood viscosity and volume, which could contribute to its antihypertensive action.

The authors explore the existing evidence and point out the lack of sufficient research regarding the hemorheological effects of amlodipine. They hypothesize that the hemodilutory properties of amlodipine, which lead to increased blood volume, may be a contributing factor to edema.

A Search for Answers in Blood Flow

This study emphasizes the need for further research to investigate the relationship between amlodipine, hemorheology, and edema. Understanding the mechanism of edema associated with amlodipine could lead to strategies for minimizing this side effect, ensuring optimal patient outcomes.

Implications for Health and Lifestyle

If you are taking amlodipine and experience swelling, it is crucial to consult your doctor. While edema is a common side effect, understanding its underlying causes can help us find ways to manage it effectively.

Dr. Camel's Conclusion

The mystery of edema associated with amlodipine is like a desert mirage, appearing tantalizingly close but remaining elusive. Exploring the intricate world of hemorheology could help us unravel this enigma and find a way to make the desert bloom with better treatment options for hypertension.

Date :
  1. Date Completed 2019-09-04
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

31000180

DOI: Digital Object Identifier

PMC6477139

SNS
PICO Info
in preparation
Languages

English

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