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The effect of lithium carbonate on affect, mood, and personality of normal subjects.

Author: AttewellP A, HubbardB, HueyL Y, JanowskyD S, JuddL L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Lithium carbonate induced substantial affect and mood changes in normal men. Lethargy, dysphoria, loss of interest in interacting with others and increased mental confusion were reported. No generalized effects were found on personality inventories.
Paper Details　
Original Abstract of the Article :
Data reflecting affect, mood, and personality attributes of 23 normal men were compared after two weeks of placebo administration and two weeks of therapeutic serum lithium levels (mean, 0.91 mEq/liter). The study was a placebo-controlled, split-half crossover, double-blind design. Affect and mood w...See full text at original site
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引用元：
https://doi.org/10.1001/archpsyc.1977.01770150104012

データ提供：米国国立医学図書館（NLM）

Lithium Carbonate: A Mood-Altering Substance

This study investigates the effects of lithium carbonate on affect, mood, and personality in normal subjects. The researchers conducted a double-blind, placebo-controlled, crossover study, exposing 23 men to two weeks of placebo administration followed by two weeks of therapeutic serum lithium levels. The study revealed significant changes in affect and mood, including lethargy, dysphoria, loss of interest in social interaction, and increased mental confusion. The study provides valuable insights into the mood-altering effects of lithium carbonate, underscoring the importance of careful monitoring and understanding its potential side effects.

Exploring the Unforeseen Terrain of Lithium Carbonate

The study's findings emphasize the need for caution when using lithium carbonate. While it can be a valuable treatment for certain conditions, its potential mood-altering effects require careful consideration. Just as a desert traveler must be aware of the unpredictable terrain and shifting sands, those taking lithium carbonate must be vigilant in observing and managing its potential side effects.

Navigating the Landscape of Mood Regulation

The study serves as a reminder of the complex landscape of mood regulation and the need for a personalized approach to treatment. Healthcare providers must carefully weigh the potential benefits and risks of lithium carbonate, considering the individual needs and circumstances of each patient. By navigating this complex terrain with expertise and compassion, we can help patients find the most effective and safe treatment options for their unique situations.

Dr. Camel's Conclusion

This study provides valuable insights into the mood-altering effects of lithium carbonate, emphasizing the importance of careful monitoring and understanding its potential side effects. By navigating the complex landscape of mood regulation with knowledge and vigilance, we can empower patients to make informed decisions about their treatment options.
Date :
  1. Date Completed 1977-04-28
  2. Date Revised 2019-07-17
Further Info :

Pubmed ID

320956

DOI: Digital Object Identifier

10.1001/archpsyc.1977.01770150104012

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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