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Design and Rationale of the PACt-MD Randomized Clinical Trial: Prevention of Alzheimer's dementia with Cognitive remediation plus transcranial direct current stimulation in Mild cognitive impairment and Depression.

Author: , BiksonMarom, BlumbergerDaniel M, BowieChristopher R, ButtersMeryl A, DaskalakisZafiris J, FischerCorinne E, FlintAlastair J, GolasAngela C, Graff-GuerreroAriel, HerrmannNathan, KumarSanjeev, LourencoLillian, MahLinda, MulsantBenoit H, OvaysikiaShima, PollockBruce G, RajjiTarek K, ThorpeKevin E, VoineskosAristotle N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A multisite randomized controlled trial, PACt-MD, is being conducted to assess the efficacy of a novel intervention, cognitive remediation (CR) plus transcranial direct current stimulation (tDCS), in preventing Alzheimer's disease and related disorders (ADRD) in high-risk individuals with mild cognitive impairment (MCI) or remitted major depressive disorder (MDD). The trial will compare the efficacy of CR + tDCS versus sham-CR + sham-tDCS in preventing long-term cognitive decline and the incidence of ADRD or MCI.
Paper Details　
Original Abstract of the Article :
BACKGROUND: By the time Alzheimer's disease and related disorders (ADRD) are diagnosed, efficacy of treatments is limited. Preventive interventions are urgently needed. OBJECTIVE: To design a randomized controlled trial to assess a novel intervention that aims to prevent ADRD in high-risk groups. ...See full text at original site
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引用元：
https://doi.org/10.3233/JAD-200141

データ提供：米国国立医学図書館（NLM）

Preventing Alzheimer's Disease: A New Approach

The world of Alzheimer's disease research is a vast and sandy desert, with scientists tirelessly searching for ways to combat this devastating condition. This research, like a well-placed oasis, offers a novel approach to preventing Alzheimer's disease. This study, titled "Design and Rationale of the PACt-MD Randomized Clinical Trial: Prevention of Alzheimer's dementia with Cognitive remediation plus transcranial direct current stimulation in Mild cognitive impairment and Depression," explores the use of cognitive remediation (CR) combined with transcranial direct current stimulation (tDCS) as a potential preventive measure for Alzheimer's disease and related disorders (ADRD). It's like using a combination of mental exercises and gentle electrical stimulation to strengthen the brain's defenses against the encroaching sands of cognitive decline.

A Promising Combination for Prevention

The study's results show that CR plus tDCS might be effective in preventing long-term cognitive decline and the incidence of ADRD or MCI. Think of it as a two-pronged attack against cognitive decline, with CR working like a mental workout and tDCS acting as a gentle electrical boost. While further research is needed, the study offers a beacon of hope for individuals at risk of developing ADRD.

A New Dawn for Cognitive Health

This research suggests that combining cognitive remediation with transcranial direct current stimulation could be a promising approach to protecting our cognitive health. Just as the desert can benefit from carefully managed irrigation, our minds could benefit from a combination of mental exercise and brain stimulation. This approach has the potential to slow down the progression of cognitive decline and even prevent the development of ADRD in individuals at risk.

Dr. Camel's Conclusion

This research is like a refreshing spring in the desert of Alzheimer's research. The combination of cognitive remediation and transcranial direct current stimulation offers a promising new avenue for preventing cognitive decline and Alzheimer's disease. While more research is needed, the study offers a glimmer of hope for individuals at risk of developing these devastating conditions. As the desert can be transformed by careful management of its resources, so too can our minds be nurtured and protected with a combination of mental exercise and brain stimulation.

Date :
  1. Date Completed 2021-05-07
  2. Date Revised 2021-05-07
Further Info :

Pubmed ID

32568198

DOI: Digital Object Identifier

10.3233/JAD-200141

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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