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Overview of novel strategies for the delivery of anthracyclines to cancer cells by liposomal and polymeric nanoformulations.

Author: AlaviMehran, VarmaRajender S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article discusses the challenges of delivering anthracyclines, a class of chemotherapy drugs, to cancer cells. The article emphasizes the importance of understanding nano-bio interactions to develop targeted formulations with low toxicity. The article explores four main strategies for improving liposomal and polymeric nanoformulations to deliver anthracyclines, including PEGylation, surface charging, targeting, and stimuli responsiveness.
Paper Details　
Original Abstract of the Article :
Severe side effects and the rapid emergence of drug resistance in cancer cells are major problems in the chemotherapy utilizing anthracyclines, with a difference between cellular response at nano and micro scale levels. Understanding this situation is more complicated issue to attain efficient targe...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijbiomac.2020.07.274

データ提供：米国国立医学図書館（NLM）

Nanotechnology: A New Frontier in Anthracycline Delivery

Anthracyclines, a class of powerful anti-cancer drugs, have revolutionized cancer treatment. However, these drugs can cause severe side effects and drug resistance can develop. This study explores the use of liposomal and polymeric nanoformulations to improve the delivery of anthracyclines to cancer cells. Researchers delve into the unique properties of nanomaterials, which allow them to target cancer cells more effectively, minimize side effects, and overcome drug resistance. The authors examine four main strategies for improving nanoformulations: PEGylation, surface charging, targeting, and stimuli responsiveness. These strategies hold the potential to revolutionize anthracycline delivery, offering a more effective and safer approach to cancer treatment.

Nanoformulations: A New Era in Anthracycline Delivery

This study underscores the potential of nanoformulations to enhance the delivery of anthracyclines to cancer cells, offering a promising approach to improve treatment effectiveness and minimize side effects. The researchers' findings highlight the importance of continuing research into the development of these innovative nanoformulations.

Navigating the Nanoworld of Cancer Treatment

The study provides a glimpse into the exciting world of nanotechnology in cancer treatment. The researchers' findings suggest that nanoformulations may offer a more precise and targeted approach to delivering anthracyclines, potentially improving treatment outcomes while minimizing side effects. The study encourages further research into the development and optimization of these innovative nanoformulations.

Dr. Camel's Conclusion

This study explores the fascinating world of nanotechnology, highlighting its potential to revolutionize the delivery of anthracyclines to cancer cells. The researchers' findings suggest that nanoformulations may offer a more effective and safer approach to cancer treatment, overcoming the challenges of traditional drug delivery methods. Just as a camel navigates the vast desert with its unique adaptations, researchers are constantly seeking new and innovative ways to combat cancer. This study serves as a beacon of hope, highlighting the potential of nanotechnology to improve the lives of cancer patients.
Date :
  1. Date Completed 2021-04-07
  2. Date Revised 2021-04-07
Further Info :

Pubmed ID

32763404

DOI: Digital Object Identifier

10.1016/j.ijbiomac.2020.07.274

SNS
PICO Info
in preparation
Languages

English

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