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Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis.

Author: , BaliaCarla, BanaschewskiTobias, BuitelaarJan K, CarucciSara, CoghillDavid, DanckaertsMarina, DittmannRalf W, GaglianoAntonella, GarasPeter, HollisChris, InglisSarah, KonradKerstin, KovshoffHanna, LampisAngelico, LiddleElizabeth B, McCarthySuzanne, NagyPeter, PaneiPietro, RomanielloRoberta, Sonuga-BarkeEdmund, UsalaTatiana, WongIan C K, ZuddasAlessandro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Long-term methylphenidate (MPH) treatment is associated with a small reduction in height and weight in children with ADHD.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth. OBJECTIVES: To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (> s...See full text at original site
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引用元：
https://doi.org/10.1016/j.neubiorev.2020.09.031

データ提供：米国国立医学図書館（NLM）

Long-Term Methylphenidate Exposure and Growth in Children with ADHD

This systematic review and meta-analysis delves into the potential effects of long-term methylphenidate (MPH) treatment on growth in children and adolescents with ADHD. The study investigates the association between MPH exposure and changes in height, weight, and pubertal development. This research aims to provide evidence-based information regarding the potential risks and benefits of long-term MPH treatment for ADHD.

Balancing Benefits and Potential Risks of MPH Treatment

The meta-analysis suggests that long-term MPH treatment is associated with small but statistically significant reductions in both height and weight in children with ADHD. However, the study also emphasizes that the effect sizes are relatively small, potentially with minimal clinical impact. The study highlights the need for continued monitoring of growth parameters in children receiving long-term MPH treatment, balancing the benefits of symptom management with potential growth-related concerns.

Informed Decision-Making for ADHD Treatment

This research provides valuable information for clinicians and families making decisions about long-term MPH treatment for ADHD. It emphasizes the importance of ongoing monitoring of growth parameters in children receiving this medication. The study highlights the need for careful consideration of the potential benefits and risks of long-term MPH treatment, ensuring the best possible outcomes for children with ADHD.

Dr.Camel's Conclusion

This research, like a desert guide leading travelers through a challenging landscape, provides valuable insights into the potential effects of long-term methylphenidate treatment for ADHD. It highlights the importance of carefully weighing the benefits and risks, reminding us that the journey of managing ADHD requires a delicate balance of therapeutic intervention and careful monitoring. This research is a testament to the ongoing efforts to understand and optimize treatment for children with ADHD, ensuring the best possible outcomes for their growth and development.

Date :
  1. Date Completed 2021-06-21
  2. Date Revised 2021-06-21
Further Info :

Pubmed ID

33080250

DOI: Digital Object Identifier

10.1016/j.neubiorev.2020.09.031

SNS
PICO Info
in preparation
Languages

English

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