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Non-specific effects of maternal and offspring rabies vaccination on mortality and antibiotic use in a Danish pig herd: A randomized trial.

Author: AabyPeter, BennChristine Stabell, JensenKristoffer Jarlov, JungersenGregers, KnobelDarryn L, KristensenCharlotte Sonne, LarsenLars Erik, TolstrupLola Kathe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the non-specific effects (NSE) of rabies vaccine in piglets, particularly the potential modifying effect of maternal priming with the vaccine.
Paper Details　
Original Abstract of the Article :
Human non-live vaccines have been associated with detrimental non-specific effects (NSE), particularly in females. A large trial found 2-fold increased overall mortality in girls receiving a new malaria vaccine compared to the rabies vaccine used as a coontrol; a beneficial NSE of the rabies vaccine...See full text at original site
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引用元：
https://doi.org/10.1016/j.vaccine.2021.03.083

データ提供：米国国立医学図書館（NLM）

Rabies Vaccination: Exploring Potential Non-Specific Effects in Pigs

The world of vaccines is constantly evolving, and researchers are always seeking to understand the full spectrum of their effects. This randomized trial explores the non-specific effects (NSE) of rabies vaccination in a Danish pig herd, examining potential influences on mortality and antibiotic use.

The researchers investigated the potential NSE of rabies vaccination in piglets, considering the possibility of modifying effects based on maternal priming. Their findings suggest that non-live rabies vaccination may have varying NSE depending on the context. The study found increased mortality in female dogs born to vaccinated mothers, but not in males.

Understanding the Complexity of Vaccine Effects

This study highlights the complex nature of NSE, suggesting that vaccine effects can vary depending on individual factors and environmental conditions.

Navigating the Landscape of Vaccine Research

The researchers' findings encourage further investigation into the potential NSE of vaccines, particularly in the context of maternal priming. Understanding the full range of vaccine effects is essential for ensuring safe and effective vaccination practices.

Dr. Camel's Conclusion

The study of non-specific effects in vaccine research is crucial for understanding the broader impact of vaccination on health. This research in Danish pigs provides valuable insights into the potential for maternal priming to influence NSE, underscoring the need for careful consideration of these factors in vaccine development and administration.

Date :
  1. Date Completed 2022-03-10
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

33840563

DOI: Digital Object Identifier

10.1016/j.vaccine.2021.03.083

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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