Paper Details

  1. Home
  2. Paper Details

Efficacy and Tolerability of Combination Treatments for Major Depression: Antidepressants plus Second-Generation Antipsychotics vs. Esketamine vs. Lithium.

Author: BahjiAnees, BaldessariniRoss J, TondoLeonardo, UndurragaJuan, VázquezGustavo H

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

Treating major depressive disorder (MDD) can be difficult, and many people don't respond well to treatment. When this happens, options include increasing the dose of antidepressants, combining medications, adding other drugs, or using non-medication therapies. However, we need more research to compare how well these different approaches work and how safe they are, especially for newer medications like second-generation antipsychotics (SGAs) and esketamine compared to lithium.
Paper Details　
Original Abstract of the Article :
Label="BACKGROUND" NlmCategory="BACKGROUND">Successful treatment of major depressive disorder (MDD) can be challenging, and failures ("treatment-resistant depression" [TRD]) are frequent. Steps to address TRD include increasing antidepressant dose, combining antidepressants, adding adjunctive agents...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358538/

データ提供：米国国立医学図書館（NLM）

Treating Major Depressive Disorder: A Comparative Analysis of Combination Therapies

The treatment of major depressive disorder (MDD) is a complex and challenging endeavor, like navigating a vast and unforgiving desert. This review, published in the Journal of Clinical Psychiatry, compares the efficacy and tolerability of different combination therapies for MDD, including antidepressants plus second-generation antipsychotics (SGAs), esketamine, and lithium. The authors conducted a thorough analysis of existing research to evaluate the relative effectiveness and safety of these approaches. This review provides valuable insights for clinicians seeking to optimize treatment strategies for MDD, particularly in cases of treatment-resistant depression (TRD).

A Desert of Treatment Options

The review highlights the need for more robust research comparing the efficacy and tolerability of different combination therapies for MDD. While SGAs, esketamine, and lithium have shown promise in treating TRD, their relative effectiveness and potential risks remain unclear. The authors emphasize the importance of individualized treatment approaches based on patient characteristics and clinical needs.

Navigating the Treatment Landscape

Just as a desert traveler must carefully choose their route and supplies, clinicians treating MDD must navigate the complex landscape of treatment options. This review provides valuable guidance in understanding the potential benefits and risks associated with different combination therapies. By carefully considering the evidence, clinicians can make informed decisions about the best course of treatment for their patients.

Dr.Camel's Conclusion

The desert of MDD can be a daunting place to traverse. This review sheds light on the complexities of treatment options and the importance of individualized care. By embracing a collaborative approach, clinicians can provide effective and compassionate care to those navigating the challenges of mental illness.

Date :
  1. Date Completed 2022-02-02
  2. Date Revised 2022-06-12
Further Info :

Pubmed ID

34238049

DOI: Digital Object Identifier

PMC8358538

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.