Contrasting effects of two xanthines, theophylline and enprofylline, on the cardio-respiratory stimulation of infused adenosine in man.

Author: AberV, BarnesP J, ConradsonT B, DixonC M, FullerR W, HughesJ M, MaxwellD L

Paper Details 
Original Abstract of the Article :
Six normal male subjects, ages 28-40 years, were studied on separate days during increasing infusions with adenosine, 40-120 micrograms kg-1 min-1, before and during infusions of two xanthine derivatives, theophylline (mean plasma concentration 9 mg l-1) and enprofylline (mean plasma concentration 3...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1111/j.1748-1716.1987.tb08262.x

データ提供:米国国立医学図書館(NLM)

The Desert of Xanthines: A Tale of Two Compounds

In the vast desert of pharmacology, we often encounter substances that interact with our bodies in unexpected ways. This study delves into the effects of two xanthine derivatives, theophylline and enprofylline, on the cardio-respiratory response to adenosine, a naturally occurring substance that plays a role in various physiological processes.

Navigating the Desert: Xanthines and Adenosine Interactions

The researchers compared the effects of theophylline and enprofylline on the heart rate and ventilation responses to adenosine infusions. They found that enprofylline augmented the effects of adenosine, while theophylline inhibited these effects. These findings suggest that xanthines, despite having similar bronchodilatory properties, can exert contrasting effects on the cardio-respiratory system.

The Desert of Drug Interactions: Understanding the Nuances

This study highlights the importance of understanding drug interactions and the potential for different compounds to exert opposing effects. It reminds us that the desert of pharmacology is full of complexities and surprises. As we navigate this desert, let's remain vigilant and seek the guidance of healthcare professionals to ensure safe and effective medication use.

Dr.Camel's Conclusion

The desert of xanthines can be a place of both wonder and caution. This study reminds us that even seemingly similar compounds can have different effects on our bodies. Like a camel navigating a desert landscape, let's be mindful of the complexities of drug interactions and seek the expertise of skilled guides (healthcare professionals) to help us navigate this challenging terrain.

Date :
  1. Date Completed 1988-02-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3425350

DOI: Digital Object Identifier

10.1111/j.1748-1716.1987.tb08262.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.