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Long-term glucocorticoid treatment and high relapse rate remain unresolved issues in the real-life management of polymyalgia rheumatica: a systematic literature review and meta-analysis.

Author: AngioniMaria Maddalena, CauliAlberto, ChessaElisabetta, CongiaMattia, ErreGian Luca, FlorisAlberto, MathieuAlessandro, PigaMatteo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and meta-analysis examined the prevalence and predictors of long-term glucocorticoid (GC) treatment and disease relapses in the real-life management of polymyalgia rheumatica (PMR). The study found that a high proportion of patients continue to take GCs for extended periods, and relapses are common. However, further research is needed to identify factors that contribute to prolonged GC use and to develop more effective steroid-sparing strategies.
Paper Details　
Original Abstract of the Article :
A systematic review and meta-analysis were conducted, according to the PRISMA methodology, to summarize current evidence on the prevalence and predictors of long-term glucocorticoid (GC) treatment and disease relapses in the real-life management of polymyalgia rheumatica (PMR).Out of 5442 retrieved ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724087/

データ提供：米国国立医学図書館（NLM）

Unraveling the Mysteries of Polymyalgia Rheumatica: A Quest for Effective Management

Polymyalgia rheumatica (PMR), a condition characterized by muscle pain and stiffness, often requires long-term treatment with glucocorticoids. This research delves into the complexities of PMR management, exploring the prevalence, predictors, and challenges associated with long-term glucocorticoid treatment and disease relapses. It's like navigating a vast, shifting desert landscape, seeking to understand the intricate interplay of factors that influence PMR progression.

A Persistent Challenge: Prolonged Glucocorticoid Use and Relapses

The study reveals a troubling reality: a high proportion of PMR patients continue to require glucocorticoid treatment for extended periods, facing a significant risk of relapses. This is like encountering a persistent sandstorm, requiring constant vigilance and adaptation to manage the ongoing challenges of the disease. The study underscores the need for innovative strategies to reduce glucocorticoid dependence and prevent relapses, akin to finding a safe haven from the relentless storm.

Navigating the Desert of Treatment

This research highlights the need for further investigation into the factors influencing long-term glucocorticoid treatment and relapse in PMR. It's like mapping a desert terrain, identifying key landmarks and pathways to guide our understanding and treatment approaches. Identifying potential predictors of prolonged glucocorticoid use and relapse is crucial for tailoring treatment plans and minimizing the risks associated with these medications.

Dr. Camel's Conclusion

This research underscores the importance of a comprehensive understanding of PMR and its treatment. It's a reminder that we must continue to explore new avenues in PMR management, seeking to reduce glucocorticoid dependence and improve patient outcomes. Like a wise camel traversing the desert, we must be persistent in our pursuit of knowledge and innovation, aiming to create a brighter future for those affected by PMR.

Date :
  1. Date Completed 2022-01-05
  2. Date Revised 2022-07-27
Further Info :

Pubmed ID

34415462

DOI: Digital Object Identifier

PMC8724087

SNS
PICO Info
in preparation
Languages

English

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