Tenofovir alafenamide nephrotoxicity: a case report and literature review.

Author: AvihingsanonAnchalee, AvihingsanonYingyos, GatechompolSivaporn, IampenkhaeKroonpong, SurintrspanontJerasit, UdomkarnjananunSuwasin, UeaphongsukkitThornthun

Paper Details 
Original Abstract of the Article :
Tenofovir alafenamide (TAF), a novel prodrug of tenofovir (TFV), has become the preferred drug for the treatment of HIV-1 and chronic hepatitis B infection in clinical practice. Results from clinical trials showed that it had better renal and bone mineral outcomes compared to tenofovir disoproxil fu...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379835/

データ提供:米国国立医学図書館(NLM)

Tenofovir Alafenamide Nephrotoxicity: A Case Report and Literature Review

The world of medicine is constantly evolving, just like the shifting sands of a desert. New drugs are developed to treat various diseases, but sometimes unexpected side effects emerge. This study examines a case of acute kidney injury in a patient using tenofovir alafenamide (TAF), a drug commonly used to treat HIV-1 and chronic hepatitis B infection. While TAF has shown promising results in clinical trials, this case report highlights the potential for adverse effects in real-world settings.

The study authors conducted a literature review to gather information on other reported cases of TAF-related nephrotoxicity. The findings suggest that while TAF is generally considered to be safer for the kidneys than its predecessor, tenofovir disoproxil fumarate (TDF), there are still risks associated with its use.

Tenofovir Alafenamide: A Potential Risk for Kidney Injury

This case report serves as a reminder that even seemingly safe drugs can have unexpected side effects. It's crucial for physicians and patients to be aware of these risks and monitor for any potential complications. This study demonstrates the importance of vigilance in medical practice, especially when using new medications.

Monitoring Kidney Function

If you are taking TAF, it's essential to keep a close eye on your kidney health. Regular monitoring of your kidney function is crucial to detect any early signs of problems. Always consult with your doctor to discuss any concerns you may have about your medications.

Dr. Camel's Conclusion

This study highlights the importance of being aware of the potential risks associated with new medications, even those considered to be safer than their predecessors. It's like traversing a desert - we must be vigilant and prepared for unexpected challenges, even when the path seems clear.

Date :
  1. Date Completed 2021-09-17
  2. Date Revised 2021-09-17
Further Info :

Pubmed ID

34419091

DOI: Digital Object Identifier

PMC8379835

SNS
PICO Info
in preparation
Languages

English

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