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An update on neuropsychiatric adverse effects with second-generation integrase inhibitors and nonnucleoside reverse transcriptase inhibitors.

Author: SennekerTessa, TsengAlice

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Neuropsychiatric adverse effects (NPAE) are a growing concern with integrase strand transfer inhibitors (INSTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs). This paper reviews the incidence, risk factors, and management of NPAE with these drugs.
Paper Details　
Original Abstract of the Article :
Neuropsychiatric adverse effects (NPAE) associated with integrase strand transfer inhibitors (INSTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are a growing concern, with higher rates in the real-world compared to phase III trials. This paper reviews the incidence, risk factors, a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34475342

データ提供：米国国立医学図書館（NLM）

Neuropsychiatric Adverse Effects: Navigating the Complexities of HIV Treatment

Treating HIV involves navigating a complex landscape of medications, each with its own unique effects and potential side effects. This research sheds light on a specific aspect of HIV treatment: the neuropsychiatric adverse effects (NPAE) associated with certain classes of drugs.

The study examines the incidence, risk factors, and management of NPAE associated with integrase strand transfer inhibitors (INSTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs). The researchers discovered that the real-world incidence of NPAE is higher than what was observed in phase III trials. This finding is like uncovering a hidden oasis in the desert of clinical research, revealing a previously unknown aspect of HIV treatment.

Understanding and Managing Neuropsychiatric Adverse Effects

The study's findings underscore the importance of understanding and managing NPAE associated with HIV treatment. This knowledge can help healthcare providers develop more personalized and effective treatment plans, ultimately improving the quality of life for patients living with HIV.

Living with HIV: Navigating the Landscape of Treatment

This research provides valuable insights for individuals living with HIV. It highlights the importance of being aware of potential side effects associated with medications and communicating openly with healthcare providers about any concerns. This approach is akin to a wise camel navigating a complex desert landscape, ensuring the safe and successful journey through HIV treatment.

Dr. Camel's Conclusion

This study underscores the complex nature of HIV treatment and the importance of careful monitoring for neuropsychiatric adverse effects. It's a reminder that the desert of HIV treatment is full of surprises, and it's crucial to stay vigilant and adapt to the changing landscape of medication and side effects.

Date :
  1. Date Completed 2021-10-22
  2. Date Revised 2023-09-03
Further Info :

Pubmed ID

34475342

DOI: Digital Object Identifier

01222929-202111000-00006

SNS
PICO Info
in preparation
Languages

English

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