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Seven-versus 14-day course of antibiotics for the treatment of bloodstream infections by Enterobacterales: a randomized, controlled trial.

Author: , Aller-GarcíaAna I, CanoÁngela, CisnerosJosé Miguel, Corzo-DelgadoJuan Enrique, Gutiérrez-GutiérrezBelén, HerreroMarta, InfanteCarmen, León-JiménezEva, López-CortésLuis E, MolinaJosé, Montero-MateosEnrique, Márquez-GómezIgnacio, NateraClara, PachónJerónimo, Praena-SegoviaJulia, RegueraJosé María, RocaCristina, Rodríguez-BañoJesús, Rosso-FernándezClara M, Torre-CisnerosJulián, ValienteLucía, Valiente-MéndezAdoración, Álvarez-MarínRocío

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This randomized trial compared 7-day and 14-day antibiotic courses for bloodstream infections caused by Enterobacterales. The 7-day course allowed for a reduction in antibiotic exposure while achieving similar clinical outcomes to the 14-day course. This suggests that shorter antibiotic courses may be effective and safe for patients with these infections.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To prove that 7-day courses of antibiotics for bloodstream infections caused by members of the Enterobacterales (eBSIs) allow a reduction in patients' exposure to antibiotics while achieving clinical outcomes similar to those of 14-day schemes. METHODS: A randomized trial was performed. ...See full text at original site
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引用元：
https://doi.org/10.1016/j.cmi.2021.09.001

データ提供：米国国立医学図書館（NLM）

Antibiotic Treatment for Bloodstream Infections: A Balancing Act

The treatment of bloodstream infections (BSI) caused by Enterobacterales, like navigating a treacherous desert landscape, requires careful consideration of antibiotic duration and patient outcomes. This study, like a skilled guide leading a caravan through a challenging terrain, explores the effectiveness of 7-day antibiotic courses versus 14-day courses for eBSI, seeking to optimize treatment while minimizing the potential risks associated with prolonged antibiotic exposure.

Shorter Antibiotic Courses: A Safe and Effective Option

This study reveals that 7-day antibiotic courses for eBSI can be just as effective as 14-day courses in achieving clinical outcomes. The researchers found no significant differences in clinical cure rates, relapse of eBSI, or relapse of fever between the two groups. This discovery, like a hidden oasis providing respite in the desert, suggests that shorter antibiotic courses can be a safe and effective alternative for patients with eBSI, potentially reducing the risks associated with prolonged antibiotic exposure.

Navigating the Desert of Infection

This study provides valuable insights into the optimal management of eBSI. The researchers' findings, like a compass guiding a caravan through the desert, highlight the importance of balancing the need for effective treatment with the potential risks associated with prolonged antibiotic exposure. By carefully weighing the benefits and risks, healthcare providers can make informed decisions regarding antibiotic duration, ultimately promoting patient well-being and minimizing the potential for adverse effects.

Dr.Camel's Conclusion

This study, like a well-worn path through the desert, highlights the importance of balancing effective treatment with minimizing unnecessary antibiotic exposure. The findings suggest that shorter antibiotic courses can be a viable option for patients with eBSI, potentially reducing the risks associated with prolonged antibiotic use.

Date :
  1. Date Completed 2022-04-05
  2. Date Revised 2022-05-05
Further Info :

Pubmed ID

34508886

DOI: Digital Object Identifier

10.1016/j.cmi.2021.09.001

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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