Effective treatment of antibiotics: A Synthesis of Findings from 45 Studies

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Original Abstract of the Article

Major Research Findings

Several studies have demonstrated the efficacy of specific antibiotics for certain infections. For instance, the study in 4 showed that imipenem/cilastatin was more cost-effective than gentamicin/clindamycin in treating serious bacterial infections because it was more effective and caused fewer side effects. Another study, found in 24 , revealed that a computerized educational module on antibiotic usage for acute respiratory infections improved patients' knowledge and attitudes toward appropriate antibiotic use. Furthermore, the research presented in 36 indicated that shorter antibiotic courses can be as effective as longer ones for many bacterial infections.

Treatment Summary

The research in 4 recommends using imipenem/cilastatin for treating serious bacterial infections. 24 suggests providing patients with acute respiratory infections with an educational module on antibiotic usage. Moreover, the findings in 36 advocate considering shorter courses of antibiotics for numerous bacterial infections.

Benefits and Risks

Benefit Summary

Antibiotics are a valuable tool for treating bacterial infections. Choosing the right antibiotic and taking it for the appropriate duration can enhance treatment effectiveness and reduce mortality. 4 demonstrated that imipenem/cilastatin is more effective than gentamicin/clindamycin. The study in 24 showed that a computerized educational module improved patients' antibiotic knowledge and attitudes. Additionally, 36 indicated that shorter antibiotic courses are just as effective as longer ones for many bacterial infections.

Risk Summary

Side effects of antibiotics include allergic reactions, digestive issues, and kidney problems. Overusing antibiotics can also contribute to the emergence of drug-resistant bacteria. Therefore, it's crucial to take antibiotics as prescribed by a doctor. Information about potential side effects can be found in these studies: 13 , 20 , 15 , 8 , 19 , 31 , 7 , 22 , 9 , 11 , 45 , , 10 , 16 , 32 , 6 , 27 , 17 , 18 , , 43 , , 34 , 39 , 23 , 21 , 25 etc.

Comparison Between Studies

Similarities

A significant number of studies emphasize the importance of selecting and using antibiotics correctly in treating infections. There's also a shared understanding that antibiotic misuse increases the risk of developing resistant bacteria. However, identifying the most effective antibiotics and determining the optimal duration of treatment depend on the specific infection, its severity, and other factors, necessitating further research.

Differences

Research studies can vary significantly in their focus, including the types of infections investigated, antibiotic types used, and study design. Simply comparing the results from different studies can be challenging. For example, 4 showed that imipenem/cilastatin was more effective than gentamicin/clindamycin, but other studies might yield different findings. When interpreting the findings of any study, considering the research design and the characteristics of the study population is essential.

Consistency and Contradictions in Results

While some studies produce consistent findings regarding antibiotic efficacy, others present contradictory results. These discrepancies are likely due to variations in research design and study populations. For instance, 36 showed that shorter antibiotic courses were as effective as longer ones for numerous bacterial infections; however, other studies have reported that shorter courses might be insufficient. Therefore, further research is crucial to comprehensively understand antibiotic efficacy.

Important Considerations for Real-World Application

Antibiotics are a valuable tool for treating bacterial infections, but overuse increases the risk of developing resistant bacteria. Therefore, it's important to follow your doctor's instructions when taking antibiotics. Additionally, antibiotics are not effective for all infections. For instance, they won't help with viral infections like the common cold. Before starting any antibiotics, consult with your doctor to choose the right treatment. Furthermore, while shorter antibiotic courses are proving effective for numerous bacterial infections, they are not suitable for all infections. If you don't see improvement with a shorter course, consult your doctor. Information regarding antibiotic usage can be found in articles such as 40 , 42 etc.

Limitations of Current Research

Numerous studies have been conducted on antibiotics; however, certain limitations persist. For example, research designs and study populations can vary, making straightforward comparison of results challenging. Additionally, data on antibiotic efficacy and safety is still accumulating. The emergence of drug-resistant bacteria is a global concern that necessitates the development of novel treatments.

Future Research Directions

Future research on antibiotics should prioritize the following areas. Firstly, conducting studies with different research designs and study populations will enable a more comprehensive understanding of antibiotic efficacy and safety. Developing novel treatments that can combat the development of drug-resistant bacteria is another crucial area. Lastly, research focused on improving patients' knowledge and attitudes regarding antibiotic usage is also important.

Conclusion

Antibiotics are effective for treating bacterial infections, but overuse can lead to drug-resistant bacteria. Follow your doctor's instructions when taking antibiotics. Antibiotics are not effective for all infections, such as viral infections like the common cold. Before starting antibiotics, consult with your doctor to choose the best treatment option.

List of Treatments

Imipenem/cilastatin, gentamicin/clindamycin, ceftriaxone, amikacin, ceftazidime, levofloxacin, daptomycin, vancomycin, teicoplanin, cloxacillin, nafcillin, oxacillin, flucloxacillin, amoxicillin, metronidazole, doxycycline, ciprofloxacin, ceftazidime, amikacin, caspofungin, amphotericin, voriconazole, ceftibuten, linezolid, aztreonam, cefalexin, etc.

Keywords
Benefit Keywords
Sepsis treatment
1
Rapid recovery with lincomycin
2
Bacteremia treatment
Pneumonia treatment
Urinary tract infection treatment
3
Antibiotic efficacy
Cost-effective
Reduced adverse reactions
4
Effective treatment
5
Infection prevention
6
Reduced treatment cost
Shorter hospital stay
9
Effective treatment for febrile neutropenia
Improved tolerance
Reduced cost
11
Respiratory infection treatment
Skin and tissue infection treatment
Urinary tract infection treatment
13
Neutropenia treatment
14
ABM treatment
15
Reduce bacterial superinfections
16
Reduced expense
Reduced resistance
Reduced toxicity
17
Infection treatment
18
Reduced mortality
19
Reduced clinical and bacteriological signs
22
Periodontal disease treatment
23
Improved knowledge
Reduced desire for antibiotics
24
Reduced antifungal use
25
Reduced antibiotic use
26
Improved oral and maxillofacial surgery outcomes
27
Improved exercise capacity
Improved quality of life
Reduced symptoms
28
Reduced mortality rates
29
Reduced side effects
Shortened hospital stay
30
Improved efficacy
Improved tolerability
31
Infection treatment
32
Bone infection treatment
Joint infection treatment
33
Improved antibiotic choice
Improved dental infection treatment
35
Reduced antibiotic resistance
Shorter antibiotic courses
36
Reduced antibiotic use
37
Infective endocarditis treatment
Oral antibiotics
38
Pain relief
Swelling reduction
39
Infectious disease treatment
40
Improved clinical outcomes
Reduced antibiotic exposure
41
Bactericidal antibiotics
Bacteriostatic antibiotics
43
Reduced antibiotic use
44
Antibiotic stewardship
45
Risk Keywords
Adverse events
1
Superinfection
3
Asthenia
Diarrhea
Dizziness
Injection pain
5
Drug resistance
Nausea and vomiting
Prolonged neutropenia
6
Doxycycline ineffective for sinusitis
7
Adverse effects
Prolonged salmonella
8
Antibiotic ineffectiveness
12
Adverse reactions
13
Adverse events
Nephrotoxicity
16
Bacteriological failure
Nephrotoxicity
19
Adverse events
20
Antibiotic resistance
26
No difference in organ failure
29
Adverse effects
Antibiotic resistance
39
Antibiotic resistance
40
Relapse of fever
41
Antibiotic resistance
42
Antibiotic resistance
45
Literature analysis of 45 papers
Positive Content
38
Neutral Content
3
Negative Content
4
Article Type
24
13
17
15
45
1.

Ceftazidime versus aminoglycoside and (ureido)penicillin combination in the empirical treatment of serious infection.

Author: FinerN, GoustasP

Sepsis treatment
Adverse events

A study of 471 patients with sepsis compared the effectiveness of ceftazidime (CAZ) monotherapy with an aminoglycoside+(ureido)penicillin combination (AG+PEN). Both regimens showed similar clinical outcomes after 72 hours and 2-4 weeks of treatment. CAZ had a slightly higher bacteriological response but not statistically significant. Adverse events were more common in the CAZ group, but deaths were primarily due to underlying conditions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

[The therapy of odontogenic abscesses. Pharmacological experimentation with lincomycin or amoxicillin].

Author: EftimiadiC, TonettiM, MoroniG L, BottaG A, SchitoG C, MangianteP E

Rapid recovery with lincomycin

This study compared the effectiveness of lincomycin and amoxicillin in treating dental abscesses caused by a mix of bacteria. Patients treated with lincomycin experienced a faster and more successful recovery compared to those treated with amoxicillin. This suggests that lincomycin may be a more effective treatment option for dental abscesses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

3.

Clinical experience with aztreonam in Europe: a summary of studies in Belgium, England, Finland, Ireland, the Netherlands, Norway, Portugal, and Sweden.

Author: NorrbyS R

Bacteremia treatment
Pneumonia treatment
Urinary tract infection treatment
Superinfection

This study evaluated the effectiveness of aztreonam in treating various bacterial infections in 342 patients. Aztreonam was highly effective for treating urinary tract infections, with a 91.5% success rate. It was also effective for pneumonia, with an 86% success rate. The drug was successful in eliminating most bacterial strains, including Pseudomonas aeruginosa. Side effects were rare and only led to one patient stopping treatment. However, four seriously ill patients developed staphylococcal infections and died. The study recommends using aztreonam in combination with other antibiotics for infections other than urinary tract infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Imipenem/cilastatin versus gentamicin/clindamycin: a cost effectiveness study.

Author: NorrbyS R, ErikssonM, OttossonE

Antibiotic efficacy
Cost-effective
Reduced adverse reactions

This study compared the cost-effectiveness of two antibiotic regimens for treating serious bacterial infections in 118 patients. One group received imipenem/cilastatin, while the other received gentamicin plus clindamycin. While imipenem/cilastatin was more expensive per day, the overall cost of treatment, including medication, equipment, and staff, was similar to the other regimen. However, imipenem/cilastatin was more effective and had fewer side effects. The study concludes that imipenem/cilastatin was more cost-effective than gentamicin plus clindamycin in treating these patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

[Results of a comparative therapeutic trial of single-dose treatment of non-complicated acute male gonorrhea].

Author: AncelleR, TorgalJ, Martin-BouyerG, ThabautA, DurosoirJ L, DolivoM, WeinmannJ M, HewittJ

Effective treatment
Asthenia
Diarrhea
Dizziness
Injection pain

A study of 636 patients with gonorrhea compared the effectiveness of four different treatments: spectinomycin, ampicillin plus probenecid, thiamphenicol, and minocycline. All four treatments were equally effective, with cure rates of 96% or higher. While all treatments were associated with some side effects, thiamphenicol caused diarrhea in 28% of patients, minocycline caused dizziness in 13%, and spectinomycin caused pain at the injection site in 18%. Based on effectiveness, side effects, and cost, the study recommends a specific treatment (not specified) for gonorrhea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

6.

Symposium on infectious complications of neoplastic disease (Part II). Chemoprophylaxis of bacterial infections in granulocytopenic patients.

Author: HenryS A

Infection prevention
Drug resistance
Nausea and vomiting
Prolonged neutropenia

Prophylactic oral nonabsorbable antibiotics may reduce the risk of infection in granulocytopenic patients, but side effects like nausea and vomiting can limit their use. Discontinuation of therapy during neutropenia is associated with life-threatening infections. The benefit of selective decontamination with trimethoprim/sulfamethoxazole remains controversial and may lead to resistant organisms or prolonged neutropenia. These regimens are not indicated for neutropenia less than 3 weeks, and the risks need to be considered even for prolonged neutropenia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

The end of antibiotic treatment in adults with acute sinusitis-like complaints in general practice? A placebo-controlled double-blind randomized doxycycline trial.

Author: StalmanW, van EssenG A, van der GraafY, de MelkerR A

Doxycycline ineffective for sinusitis

Doxycycline did not improve the effectiveness of decongestive nose drops and steam inhalation for treating acute sinusitis-like complaints in adults.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Antibiotics for treating salmonella gut infections.

Author: SirinavinS, GarnerP

Adverse effects
Prolonged salmonella

Antibiotic therapy does not appear to be clinically beneficial for otherwise healthy adults and children with non-severe salmonella diarrhea. Antibiotics may increase adverse effects and prolong salmonella detection in stools.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

[Community acquired pneumonia: from intravenous to oral cephalosporin sequential therapy].

Author: FernándezP, San MartínL

Reduced treatment cost
Shorter hospital stay

Patients with community-acquired pneumonia who showed good initial response to intravenous ceftriaxone could safely be switched to oral therapy with ceftibuten. Both treatment groups showed no difference in clinical cure, radiological improvement, or normalization of white blood cell count.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

10.

The management of bacterial infections of the upper respiratory tract in children: pharyngitis and otitis media.

Author: AdamD

While the types of bacteria causing ear infections (otitis media) and sore throats (pharyngitis) can change, the main antibiotics used to treat them remain effective. However, newer antibiotics are now used when first-line drugs fail or are not appropriate. The study acknowledges that the benefit of antibiotics for sore throats in children is still debated, but in practice, antibiotics are often used.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Single-daily ceftriaxone plus amikacin versus thrice-daily ceftazidime plus amikacin as empirical treatment of febrile neutropenia in children with cancer.

Author: AriffinH, ArasuA, MahfuzahM, AriffinW A, ChanL L, LinH P

Effective treatment for febrile neutropenia
Improved tolerance
Reduced cost

Single-daily ceftriaxone plus amikacin was evaluated as an alternative to thrice-daily ceftazidime plus amikacin for febrile neutropenic patients. The study compared efficacy, safety, tolerance, and cost of the two regimens.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Re-evaluation of a randomized controlled trial of antibiotics for minor respiratory illness in general practice.

Author: FaheyT, HowieJ

Antibiotic ineffectiveness

A review of six randomized controlled trials found little benefit of antibiotics for acute respiratory illness. One trial was excluded due to a possible confounding factor of multiple episodes of illness in the analysis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

A randomized controlled clinical trial on etimicin, a new aminoglycoside antibiotic, versus netilmicin in the treatment of bacterial infections.

Author: ZhaoC, LiJ, HouJ, GuoM, ZhangY, ChenY

Respiratory infection treatment
Skin and tissue infection treatment
Urinary tract infection treatment
Adverse reactions

Etimicin and netilmicin were both effective and safe for the treatment of respiratory tract infections, urinary tract infections, and skin and tissue infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Evaluation of ticarcillin/clavulanic acid versus ceftriaxone plus amikacin for fever and neutropenia in pediatric patients with leukemia and lymphoma.

Author: PetrilliAntonio Sérgio, CyprianoMonica, DantasLenice Silva, LeeLúcia Martino, Vercillo LuisiMaria Flávio Augusto, Torres B SilvaKatia Veronica, Pires PereiraCarlos Alberto

Neutropenia treatment

Ticarcillin/clavulanic acid was found to be as successful as the combination of ceftriaxone plus amikacin in pediatric and adolescent patients with leukemia or lymphoma who presented with fever and neutropenia during chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Third generation cephalosporins versus conventional antibiotics for treating acute bacterial meningitis.

Author: PrasadK, SinghalT, JainN, GuptaP K

ABM treatment

Treatment for suspected bacterial meningitis needs to begin immediately, even before test results are available. It is unclear whether newer cephalosporin antibiotics are better than the traditional combination of ampicillin and chloramphenicol. Prompt and effective intravenous treatment can reduce deaths and long-term disabilities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Empirical antibiotics against Gram-positive infections for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials.

Author: PaulMical, BorokSara, FraserAbigail, VidalLiat, LeiboviciLeonard

Reduce bacterial superinfections
Adverse events
Nephrotoxicity

Glycopeptides can be safely deferred until the documentation of a resistant Gram-positive infection in the treatment of febrile neutropenia, as there was no significant difference in all-cause mortality between groups receiving empirical anti-Gram-positive antibiotics and control groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Empirical atypical coverage for inpatients with community-acquired pneumonia: systematic review of randomized controlled trials.

Author: ShefetDaphna, RobenshtokEyal, PaulMical, LeiboviciLeonard

Reduced expense
Reduced resistance
Reduced toxicity

This study assessed the efficacy of empirical coverage for atypical pathogens in treating inpatients with community-acquired pneumonia, questioning the necessity of such coverage and highlighting potential benefits of limiting it.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence.

Author: FalagasMatthew E, MantaKaterina G, NtzioraFotinie, VardakasKonstantinos Z

Infection treatment

Linezolid is an antibiotic effective against certain bacteria (Gram-positive cocci) that causes infections like pneumonia, skin infections, and potentially bloodstream infections. While it's mainly used for these conditions, it's sometimes used for treating heart valve infections (endocarditis) caused by bacteria resistant to other antibiotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Efficacy and safety of aminoglycoside monotherapy: systematic review and meta-analysis of randomized controlled trials.

Author: VidalLiat, Gafter-GviliAnat, BorokSara, FraserAbigail, LeiboviciLeonard, PaulMical

Reduced mortality
Bacteriological failure
Nephrotoxicity

Aminoglycosides are effective for urinary tract infections, but there is insufficient evidence to recommend their use for other infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Safety profile of cefditoren. A pooled analysis of data from clinical trials in community-acquired respiratory tract infections.

Author: GranizoJ J, AguilarL, GimenezM J, CoronelP, GimenoM, PrietoJ

Adverse events

This review examines the adverse events profile related to antibiotic exposure during clinical drug development.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Empirical antimicrobial therapy of acute dentoalveolar abscess.

Author: MatijevićStevo, LazićZoran, Kuljić-KapulicaNada, NonkovićZorka

This study investigated the clinical efficiency of amoxicillin and cefalexin in the empirical treatment of acute odontogenic abscess.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Antibiotics for the treatment of dysentery in children.

Author: TraaBeatrix S, WalkerChrista L Fischer, MunosMelinda, BlackRobert E

Reduced clinical and bacteriological signs

Ciprofloxacin, ceftriaxone, and pivmecillinam, antibiotics recommended by the World Health Organization (WHO) for dysentery in children, are effective in reducing clinical and bacteriological signs and symptoms of dysentery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

[Efficient, minimally invasive periodontal therapy. An evidence based treatment concept].

Author: MombelliAndrea, DécailletFabien, AlmaghlouthAdnan, WickPhilipp, CioncaNorbert

Periodontal disease treatment

While antibiotics have shown benefits in treating gum disease, the specific benefits and risks in different situations are still debated. Research suggests that combining antibiotics with a procedure called subgingival debridement (cleaning below the gum line) may reduce the need for gum surgery. However, antibiotics should not replace proper cleaning or good oral hygiene. This review recommends a treatment protocol based on current evidence, highlighting that most cases of severe gum disease can be treated effectively and affordably with non-surgical methods.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

24.

A computerized education module improves patient knowledge and attitudes about appropriate antibiotic use for acute respiratory tract infections.

Author: PriceErika Leemann, MackenzieThomas D, MetlayJoshua P, CamargoCarlos A, GonzalesRalph

Improved knowledge
Reduced desire for antibiotics

An interactive educational kiosk improved knowledge about antibiotics and ARIs, which correlated with decreased desire for antibiotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Galactomannan-guided preemptive vs. empirical antifungals in the persistently febrile neutropenic patient: a prospective randomized study.

Author: TanBan Hock, LowJenny Guek Hong, ChlebickaNidhi L, KurupAsok, CheahFoong Koon, LinRaymond Tzer Pin, GohYeow Tee, WongGee Chuan

Reduced antifungal use

A preemptive approach may reduce empirical antifungal use without compromising survival in persistently febrile neutropenic patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

A prospective, multi centre, randomized clinical study to compare the efficacy and safety of Ertapenem 3 days versus Ampicillin-Sulbactam 3 days in the treatment of localized community acquired intra-abdominal infection. (T.E.A. Study: Three days Ertapenem vs three days Ampicillin-sulbactam).

Author: CoccoliniFederico, CatenaFausto, AnsaloniLuca, ErcolaniGiorgio, Di SaverioSalomone, GazzottiFilippo, LazzareschiDaniel, PinnaAntonio D

Reduced antibiotic use
Antibiotic resistance

The optimal duration of antibiotic therapy for intra-abdominal infections is debated. This study examines the use of ampicillin-sulbactam, a common antibiotic for these infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

What are the antibiotics of choice for odontogenic infections, and how long should the treatment course last?

Author: FlynnThomas R

Improved oral and maxillofacial surgery outcomes

This review found that standard antibiotics are effective in treating infections when combined with surgery, despite concerns about resistance. The choice of antibiotic should be guided by safety and cost considerations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Amoxicillin for acute rhinosinusitis: a randomized controlled trial.

Author: GarbuttJane M, BanisterChristina, SpitznagelEdward, PiccirilloJay F

Improved exercise capacity
Improved quality of life
Reduced symptoms

Amoxicillin did not reduce symptoms of acute rhinosinusitis at day 3 of treatment compared with placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

29.

Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.

Author: BrunkhorstFrank M, OppertMichael, MarxGernot, BloosFrank, LudewigKatrin, PutensenChristian, NierhausAxel, JaschinskiUlrich, Meier-HellmannAndreas, WeylandAndreas, GründlingMatthias, MoererOnnen, RiessenReimer, SeibelArmin, RagallerMaximilian, BüchlerMarkus W, JohnStefan, BachFriedhelm, SpiesClaudia, ReillLorenz, FritzHarald, KiehntopfMichael, KuhntEvelyn, BogatschHolger, EngelChristoph, LoefflerMarkus, KollefMarin H, ReinhartKonrad, WelteTobias,

Reduced mortality rates
No difference in organ failure

Treatment with combined meropenem and moxifloxacin compared with meropenem alone did not result in less organ failure in adult patients with severe sepsis. There was no statistically significant difference in the rates of 28-day and 90-day mortality between the two groups.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Partial oral treatment of endocarditis.

Author: IversenKasper, HøstNis, BruunNiels Eske, ElmingHanne, PumpBettina, ChristensenJens Jørgen, GillSabine, RosenvingeFlemming, WiggersHenrik, FuurstedKurt, Holst-HansenClaus, KorupEva, SchønheyderHenrik Carl, HassagerChristian, HøfstenDan, LarsenJannik Helweg, MoserClaus, IhlemannNikolaj, BundgaardHenning

Reduced side effects
Shortened hospital stay

Current guidelines recommend giving antibiotics through a vein (intravenously) for 4-6 weeks to treat left-sided infective endocarditis (IE). Switching to oral antibiotics in patients who are stable could reduce side effects and hospital stays. While there's limited evidence, some observations suggest that this approach might be safe and effective.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections.

Author: ShiuJennifer, WangErica, TejaniAaron M, WasdellMichael

Improved efficacy
Improved tolerability

Intravenous broad-spectrum antibiotics are used to treat severe infections. However, the emergence of drug-resistant bacteria has led to a search for new dosing strategies. This review will examine the use of continuous infusions compared to intermittent infusions of antibiotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Trial of short-course antimicrobial therapy for intraabdominal infection.

Author: SawyerRobert G, ClaridgeJeffrey A, NathensAvery B, RotsteinOri D, DuaneTherese M, EvansHeather L, CookCharles H, O'NeillPatrick J, MazuskiJohn E, AskariReza, WilsonMark A, NapolitanoLena M, NamiasNicholas, MillerPreston R, DellingerE Patchen, WatsonChristopher M, CoimbraRaul, DentDaniel L, LowryStephen F, CocanourChristine S, WestMichaela A, BantonKaysie L, CheadleWilliam G, LipsettPamela A, GuidryChristopher A, PopovskyKimberley,

Infection treatment

The outcomes of fixed-duration antibiotic therapy (approximately 4 days) were similar to those after a longer course of antibiotics (approximately 8 days) in patients with intraabdominal infections who had undergone an adequate source-control procedure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

33.

Oral versus intravenous antibiotic treatment for bone and joint infections (OVIVA): study protocol for a randomised controlled trial.

Author: LiHo Kwong, ScarboroughMatthew, ZambellasRhea, CooperCushla, RombachInes, WalkerA Sarah, LipskyBenjamin A, BriggsAndrew, SeatonAndrew, AtkinsBridget, WoodhouseAndrew, BerendtAnthony, ByrenIvor, AngusBrian, PanditHemant, StubbsDavid, McNallyMartin, ThwaitesGuy, BejonPhilip

Bone infection treatment
Joint infection treatment

This study investigates whether oral antibiotics are as effective as intravenous antibiotics for bone and joint infections in adults, considering the risks and costs associated with intravenous therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

A comparison of different antibiotic regimens for the treatment of infective endocarditis.

Author: Martí-CarvajalArturo J, DayerMark, ConternoLucieni O, Gonzalez GarayAlejandro G, Martí-AmaristaCristina Elena, Simancas-RacinesDaniel

This Cochrane review assessed the existing evidence regarding the efficacy and safety of various antibiotic regimens for treating infective endocarditis. Limited and very low quality evidence suggested no conclusive differences between antibiotic regimens in terms of cure rates or other clinical outcomes. Due to the low quality of evidence, further research is needed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

The Use of Antibiotics in Odontogenic Infections: What Is the Best Choice? A Systematic Review.

Author: MartinsJoão Roig, ChagasOtacílio Luiz, VelasquesBibiana Dalsasso, BobrowskiÂngelo Niemczewski, CorreaMarcos Britto, TorrianiMarcos Antonio

Improved antibiotic choice
Improved dental infection treatment

Antibiotics are often used in addition to removing the source of infection to treat odontogenic infections, a common dental problem. This study explores the optimal use of antibiotics for dental infections, including the most effective drugs and duration of treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Shortened Courses of Antibiotics for Bacterial Infections: A Systematic Review of Randomized Controlled Trials.

Author: HanrettyAlexandra M, GallagherJason C

Reduced antibiotic resistance
Shorter antibiotic courses

This systematic review investigated the efficacy of shorter versus longer durations of antibiotic therapy for six common bacterial infections: community-acquired pneumonia, ventilator-associated pneumonia, intraabdominal infections, skin and soft tissue infections, uncomplicated cystitis, and complicated cystitis or pyelonephritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Can biomarkers improve the rational use of antibiotics?

Author: FontelaPatricia S, O'DonnellShauna, PapenburgJesse

Reduced antibiotic use

Procalcitonin and C-reactive protein (CRP) are biomarkers that can be used to guide antibiotic treatment decisions for bacterial infections, especially for respiratory infections. These biomarkers can help reduce unnecessary antibiotic use. However, more research is needed on the utility of neutrophil CD64 and serum amyloid A as biomarkers for tailoring antibiotic use. Transcriptomics, metabolomics and proteomics are promising tools for the development of tests to differentiate host responses to viral, bacterial and noninfectious stimuli. However, further validation of these tests is necessary.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

38.

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis.

Author: IversenKasper, IhlemannNikolaj, GillSabine U, MadsenTrine, ElmingHanne, JensenKaare T, BruunNiels E, HøfstenDan E, FurstedKurt, ChristensenJens J, SchultzMartin, KleinChristine F, FosbøllEmil L, RosenvingeFlemming, SchønheyderHenrik C, KøberLars, Torp-PedersenChristian, Helweg-LarsenJannik, TønderNiels, MoserClaus, BundgaardHenning

Infective endocarditis treatment
Oral antibiotics

People with a heart infection (infective endocarditis) on the left side of the heart are usually treated with intravenous antibiotics for up to six weeks. It's unclear if switching to oral antibiotics once the patient is stable would be as effective and safe as continuing intravenous treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Antibiotics for the urgent management of symptomatic irreversible pulpitis, symptomatic apical periodontitis, and localized acute apical abscess: Systematic review and meta-analysis-a report of the American Dental Association.

Author: TampiMalavika P, PilcherLauren, UrquhartOlivia, KennedyErinne, O'BrienKelly K, LockhartPeter B, AbtElliot, AminoshariaeAnita, DurkinMichael J, FouadAshraf F, GopalPrerna, HattenBenjamin W, LangMelanie S, PattonLauren L, PaumierThomas, SudaKatie J, ChoHannah, Carrasco-LabraAlonso

Pain relief
Swelling reduction
Adverse effects
Antibiotic resistance

Antibiotics are frequently prescribed for patients with pulpal and periapical conditions, even when conservative dental treatment (DCDT) is an option. This review summarizes the evidence on the effectiveness of antibiotics, alone or as an adjunct to DCDT, for treating immunocompetent adults with pulpal and periapical conditions. It also explores the potential negative consequences of antibiotic use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Prevention of antibiotic resistance - an epidemiological scoping review to identify research categories and knowledge gaps.

Author: WallStig

Infectious disease treatment
Antibiotic resistance

Antibiotics have saved countless lives, but their overuse has led to drug resistance, meaning they are becoming less effective. This is a major global health crisis, as serious as terrorism and climate change, threatening our health, food supply, and development.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Seven-versus 14-day course of antibiotics for the treatment of bloodstream infections by Enterobacterales: a randomized, controlled trial.

Author: MolinaJosé, Montero-MateosEnrique, Praena-SegoviaJulia, León-JiménezEva, NateraClara, López-CortésLuis E, ValienteLucía, Rosso-FernándezClara M, HerreroMarta, Aller-GarcíaAna I, CanoÁngela, Gutiérrez-GutiérrezBelén, Márquez-GómezIgnacio, Álvarez-MarínRocío, InfanteCarmen, RocaCristina, Valiente-MéndezAdoración, PachónJerónimo, RegueraJosé María, Corzo-DelgadoJuan Enrique, Torre-CisnerosJulián, Rodríguez-BañoJesús, CisnerosJosé Miguel,

Improved clinical outcomes
Reduced antibiotic exposure
Relapse of fever

This randomized trial compared 7-day and 14-day antibiotic courses for bloodstream infections caused by Enterobacterales. The 7-day course allowed for a reduction in antibiotic exposure while achieving similar clinical outcomes to the 14-day course. This suggests that shorter antibiotic courses may be effective and safe for patients with these infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli (endorsed by European society of intensive care medicine).

Author: PaulMical, CarraraElena, RetamarPilar, TängdénThomas, BittermanRoni, BonomoRobert A, de WaeleJan, DaikosGeorge L, AkovaMurat, HarbarthStephan, PulciniCeline, Garnacho-MonteroJosé, SemeKatja, TumbarelloMario, LindemannPaul Christoffer, GandraSumanth, YuYunsong, BassettiMatteo, MoutonJohan W, TacconelliEvelina, Rodríguez-BañoJesús

Antibiotic resistance

These guidelines provide recommendations for the targeted antibiotic treatment of third-generation cephalosporin-resistant Enterobacterales (3GCephRE) and carbapenem-resistant Gram-negative bacteria. Due to limited evidence, most recommendations are based on very-low- and low-certainty evidence. The guidelines emphasize the importance of antibiotic stewardship, including carbapenem-sparing options for 3GCephRE and limiting the use of new antibiotics for severe infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Mortality and clinical cure rates for pneumonia: a systematic review, meta-analysis, and trial sequential analysis of randomized control trials comparing bactericidal and bacteriostatic antibiotic treatments.

Author: SaleemNaveed, RyckaertFrancis, SnowTimothy Arthur Chandos, SattaGiovanni, SingerMervyn, ArulkumaranNishkantha

Bactericidal antibiotics
Bacteriostatic antibiotics

This systematic review, meta-analysis, and trial sequential analysis (TSA) compared the effectiveness of bactericidal and bacteriostatic antibiotics for the treatment of pneumonia. The results showed no significant difference between the two types of antibiotics in terms of clinical cure rate, mortality, microbiological eradication, treatment failure, or relapse rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Diagnostic prediction models for CT-confirmed and bacterial rhinosinusitis in primary care: individual participant data meta-analysis.

Author: TakadaToshihiko, HooglandJeroen, HansenJens G, LindbaekMorten, AutioTimo, AlhoOlli-Pekka, EbellMark H, ReitsmaJohannes B, VenekampRoderick P

Reduced antibiotic use

Simple prediction models for CT-confirmed ARS and culture-confirmed ABRS can be useful to safely reduce antibiotic use in adults with ARS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

The Burden of Self-Reported Antibiotic Allergies in Health Care and How to Address It: A Systematic Review of the Evidence.

Author: ArnoldAnnabelle, CoventryLinda L, FosterMandie J, KoplinJennifer J, LucasMichaela

Antibiotic stewardship
Antibiotic resistance

This study explores the impact of unconfirmed reported antibiotic allergies on antimicrobial stewardship in healthcare. Antibiotic overuse and inappropriate prescribing are a significant concern, leading to antimicrobial resistance. Unconfirmed allergies can hinder the appropriate use of antibiotics.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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