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A systematic review of the pharmacotherapy of secondary hyperparathyroidism (SHPT) in grades 3-5 Chronic Kidney Disease (CKD).

Author: Idasiak-PiechockaI, LackaK, MiedziaszczykM, WiśniewskiO W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review found that calcifediol ER, paricalcitol, and cinacalcet all significantly decreased intact parathyroid hormone (iPTH) levels in patients with secondary hyperparathyroidism (SHPT) and chronic kidney disease (CKD). Paricalcitol was associated with the highest increase in serum calcium concentration. Cinacalcet was the only drug that did not carry a risk of hypercalcemia.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The data on the treatment of secondary hyperparathyroidism (SHPT) provided in scientific publications are divergent and contradictory. Therefore, the aim of our systematic review was to evaluate the efficacy of SHPT treatment in (chronic kidney disease) CKD. MATERIALS AND METHODS: The Co...See full text at original site
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引用元：
https://doi.org/10.26355/eurrev_202201_27773

データ提供：米国国立医学図書館（NLM）

A systematic review of the pharmacotherapy of secondary hyperparathyroidism (SHPT) in grades 3-5 Chronic Kidney Disease (CKD)

Chronic kidney disease (CKD) is like a complex ecosystem, with many interconnected factors that influence its progression. This study, like a meticulous ecologist studying the delicate balance of this ecosystem, systematically reviews the pharmacotherapy options for secondary hyperparathyroidism (SHPT) in patients with CKD. It evaluates the efficacy and side effects of various medications used to treat SHPT, providing valuable insights for clinicians.

Pharmacotherapy for SHPT: finding the right balance in the CKD ecosystem

The study reveals that several medications, including calcifediol, calcitriol, paricalcitol, and cinacalcet, can effectively reduce iPTH levels in CKD patients. However, it also highlights the need for careful monitoring due to potential side effects such as hypercalcemia. The study suggests that while calcifediol ER, paricalcitol, and cinacalcet can effectively lower iPTH levels, only cinacalcet does not carry the risk of hypercalcemia.

Maintaining balance in the CKD ecosystem

This study underscores the importance of individualized treatment approaches for CKD patients, considering the complex interplay between various medications and potential side effects. It emphasizes the need for close monitoring and adjustments to treatment plans to achieve optimal outcomes for patients.

Dr. Camel's Conclusion

This study, like a desert explorer navigating a complex landscape, provides a comprehensive overview of pharmacotherapy options for SHPT in CKD patients. It highlights the need for careful consideration of both benefits and risks when choosing treatment strategies, ensuring that patients receive the most appropriate and effective care for their unique needs.
Date :
  1. Date Completed 2022-04-07
  2. Date Revised 2022-04-07
Further Info :

Pubmed ID

35049000

DOI: Digital Object Identifier

10.26355/eurrev_202201_27773

SNS
PICO Info
in preparation
Languages

English

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