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Anthracycline derivatives inhibit cardiac CYP2J2.

Author: ArangoAndres S, ArnoldWilliam R, DasAditi, KimJustin S, ShahSwapnil, TajkhorshidEmad

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
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Overview

This study investigated the interaction of anthracycline derivatives with CYP2J2, an enzyme involved in the production of cardioprotective epoxyeicosatrienoic acids (EETs). The findings suggest that anthracyclines can inhibit CYP2J2, potentially contributing to cardiotoxicity.
Paper Details　
Original Abstract of the Article :
Anthracycline chemotherapeutics are highly effective, but their clinical usefulness is hampered by adverse side effects such as cardiotoxicity. Cytochrome P450 2J2 (CYP2J2) is a cytochrome P450 epoxygenase in human cardiomyocytes that converts arachidonic acid (AA) to cardioprotective epoxyeicosatri...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/35078036

データ提供：米国国立医学図書館（NLM）

Investigating the Impact of Anthracycline Derivatives on Cardiac Function

This study delves into the complex relationship between anthracycline chemotherapeutics, commonly used to treat cancer, and cardiac function. The researchers focus on the potential cardiotoxicity of anthracyclines, investigating how these drugs interact with a critical enzyme in the heart, cytochrome P450 2J2 (CYP2J2), which plays a role in protecting the heart from damage.

Unveiling the Mechanisms of Anthracycline Cardiotoxicity

The study reveals that anthracycline derivatives can bind to and inhibit CYP2J2, potentially disrupting the production of cardioprotective molecules. This finding sheds light on a potential mechanism underlying anthracycline-induced cardiotoxicity, providing valuable insights for understanding the complex interplay between cancer treatment and heart health.

Navigating the Balance Between Cancer Treatment and Heart Health

This research emphasizes the importance of carefully considering the potential risks and benefits of anthracycline therapy. The findings highlight the need for monitoring cardiac function in patients receiving anthracycline treatment and exploring alternative therapeutic approaches to minimize cardiotoxicity. Just as a skilled desert traveler navigates treacherous terrain, healthcare professionals must navigate the delicate balance between cancer treatment and heart health.

Dr. Camel's Conclusion

This research reminds us that the desert of cancer treatment is often fraught with challenges. The study's findings underscore the importance of understanding the intricate mechanisms involved in drug-induced cardiotoxicity, enabling us to develop more targeted and less toxic therapies for cancer. The findings also highlight the importance of personalized medicine, where treatment strategies are tailored to the individual patient's needs and risk factors. Just as a camel adapts to the harsh desert environment, we must adapt our treatment strategies to ensure the best possible outcomes for cancer patients.

Date :
  1. Date Completed 2022-03-14
  2. Date Revised 2023-04-02
Further Info :

Pubmed ID

35078036

DOI: Digital Object Identifier

NIHMS1773104

SNS
PICO Info
in preparation
Languages

English

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