Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial.

Author: AllaartCornelia F, BoerAleid C, BurgersLeonie E, BöhringerStefan, DakkakYousra J, HuizingaTom W J, KokMarc R, KrijbolderDoortje I, MolenaarEsmeralda T H, NiemantsverdrietEllis, ParkYune Jung, VerstappenMarloes, VisserKaren, de JongPascal H P, de Witt-LuthMarianne E, van DijkBastiaan T, van der Helm-van MilAnnette H M

Paper Details 
Original Abstract of the Article :
Rheumatoid arthritis is the most common autoimmune disease worldwide and requires long-term treatment to suppress inflammation. Currently, treatment is started when arthritis is clinically apparent. We aimed to evaluate whether earlier intervention, in the preceding phase of arthralgia and subclinic...See full text at original site
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引用元:
https://doi.org/10.1016/S0140-6736(22)01193-X

データ提供:米国国立医学図書館(NLM)

Treating Arthralgia Early: Can We Prevent Rheumatoid Arthritis?

This research explores the potential of early intervention with methotrexate in patients experiencing arthralgia, a precursor to rheumatoid arthritis. Imagine a desert oasis where some travelers are experiencing early signs of dehydration, potentially leading to a more serious illness. This research seeks to determine if early intervention can prevent this progression.

Early Intervention with Methotrexate for Arthralgia

The study aims to evaluate whether early intervention with methotrexate can prevent the development of clinical arthritis or reduce its severity in patients with arthralgia. It's like providing a small sip of water to the travelers experiencing early signs of dehydration, potentially preventing a more serious illness.

The Promise of Early Intervention

The study highlights the potential benefits of early intervention in autoimmune diseases. Early intervention can potentially prevent the development of more severe symptoms and improve the long-term health of patients. It's like having a desert guide who recognizes the early signs of dehydration and provides timely intervention to prevent a more serious health crisis.

Dr.Camel's Conclusion

This study is a reminder of the importance of early intervention in autoimmune diseases. By understanding the early signs of these conditions, researchers can develop new treatments and strategies to prevent or minimize their impact on patients. It's like having a desert oasis that offers early intervention and support to travelers, helping them avoid the dangers of the desert.

Date :
  1. Date Completed 2022-07-26
  2. Date Revised 2022-07-26
Further Info :

Pubmed ID

35871815

DOI: Digital Object Identifier

10.1016/S0140-6736(22)01193-X

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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