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Retrobulbar Injection of Amphotericin B in Patients With COVID-19 Associated Orbital Mucormycosis: A Systematic Review.

Author: AkbariZahra, NasiriNaser, Shafie'eiMohammad, ShafieiMohadeseh, SharifiAli, SharifiMeraj, ZandAmin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study examines the protocols, outcomes, and side effects of retrobulbar amphotericin B injections for globe salvage in patients with COVID-19-associated rhino-orbito-cerebral mucormycosis.
Paper Details　
Original Abstract of the Article :
Following COVID-19 infection a rising count of rhino-orbito-cerebral mucormycosis is observed, requiring orbital exenteration, a disabling lifetime affecting surgery. One of the potential interventions for globe salvage in these patients is retrobulbar injections of amphotericin B. This study was co...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451608/

データ提供：米国国立医学図書館（NLM）

A New Frontier in Mucormycosis Treatment: Retrobulbar Amphotericin B

Mucormycosis, a severe fungal infection, has become increasingly prevalent in patients with COVID-19, often leading to devastating complications affecting the sinuses, eyes, and brain. This research explores the use of retrobulbar injections of amphotericin B, an antifungal medication, as a potential treatment for COVID-19-associated orbital mucormycosis (CAM). The researchers conducted a systematic review of existing protocols, outcomes, and side effects of this novel treatment approach.

A Potential Globe-Saving Strategy

The review highlighted the potential of retrobulbar amphotericin B injections in preserving vision and preventing orbital exenteration, a disfiguring surgery often required for CAM. However, the evidence base for this approach is still limited, with most studies being case reports or small case series. Further research is crucial to establish the efficacy and safety of this treatment modality.

A Hopeful Approach to a Challenging Condition

The research suggests that retrobulbar amphotericin B injections offer a promising approach to treating CAM, potentially mitigating the need for orbital exenteration and preserving vision. Further research is needed to optimize protocols, identify ideal patient candidates, and assess long-term outcomes. This approach may represent a valuable addition to the therapeutic arsenal for managing CAM, offering a glimmer of hope for patients facing this challenging condition.

Dr.Camel's Conclusion

The journey of CAM treatment can be fraught with difficult choices. This research explores a new path, highlighting the potential of retrobulbar amphotericin B injections in preserving vision and preventing devastating complications. While further research is needed to solidify its place in the treatment landscape, this approach offers a glimmer of hope for patients facing this challenging condition.

Date :
  1. Date Completed 2022-09-13
  2. Date Revised 2023-08-17
Further Info :

Pubmed ID

35943425

DOI: Digital Object Identifier

PMC9451608

SNS
PICO Info
in preparation
Languages

English

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