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Stiripentol for Drug-Resistant Epilepsy Treatment in Tuberous Sclerosis Complex.

Author: AungaroonGewalin, FranzDavid N, HornPaul S, MehtaAmar

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Stiripentol (STP) was evaluated as a treatment for drug-resistant epilepsy (DRE) in patients with tuberous sclerosis complex (TSC). Approximately 46% of patients had favorable outcomes, defined as at least 50% seizure reduction, and younger age, early treatment, higher doses, and higher baseline seizure frequency were associated with better outcomes. Although side effects were common, STP may be a viable treatment option for DRE in TSC.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Drug-resistant epilepsy (DRE) is common in tuberous sclerosis complex (TSC). The role of stiripentol (STP) in seizure treatment in this population is not well understood. This study evaluates the efficacy and tolerability of STP in patients with TSC with DRE. METHODS: We performed a ret...See full text at original site
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引用元：
https://doi.org/10.1016/j.pediatrneurol.2022.11.017

データ提供：米国国立医学図書館（NLM）

Stiripentol: A Potential Oasis for Drug-Resistant Epilepsy in Tuberous Sclerosis Complex

Tuberous sclerosis complex (TSC) is a rare genetic disorder that can cause a range of symptoms, including drug-resistant epilepsy (DRE). This study examines the efficacy and safety of stiripentol (STP), an anticonvulsant medication, in treating DRE in patients with TSC. The authors conducted a retrospective review of patients with TSC and DRE who were treated with STP. The research indicates that STP can be effective in reducing seizure frequency in a significant proportion of patients with TSC and DRE. The study also highlights the importance of factors such as age, timing of treatment initiation, and dose in influencing treatment outcomes.

Stiripentol: A Glimpse of Hope in the Desert of Drug-Resistant Epilepsy

The research provides a ray of hope for patients with TSC and DRE. The study shows that STP can significantly reduce seizure frequency in a substantial number of patients. This finding suggests that STP might be a valuable therapeutic option for patients with TSC and DRE who have not responded to other medications. The study also highlights the importance of personalized treatment approaches, considering factors such as age and treatment initiation timing.

Navigating the Desert of TSC and DRE

The complex landscape of TSC and DRE can be daunting, but this study provides valuable insights into potential treatment strategies. The research on STP offers a glimmer of hope for patients with TSC and DRE who are struggling to manage their seizures. The authors emphasize the importance of early treatment initiation, appropriate dosing, and a personalized approach to maximize the benefits of STP for patients with TSC and DRE.

Dr.Camel's Conclusion

The desert of TSC and DRE can be a challenging environment, but this study reveals a potential oasis of hope in the form of stiripentol. This anticonvulsant medication shows promise in reducing seizures in patients with TSC and DRE, providing valuable insights into potential treatment strategies.

Date :
  1. Date Completed 2023-01-17
  2. Date Revised 2023-02-18
Further Info :

Pubmed ID

36586162

DOI: Digital Object Identifier

10.1016/j.pediatrneurol.2022.11.017

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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